Project Grant 20246701542736
- Summary: HPAI Immunoprophylactic Strategy Development The University of Georgia Research Foundation, Inc. received a $1,999,861 Cooperative Agreement award from the U.S. Department of Agriculture's Animal and Plant Health Inspection Service (APHIS) under the Plant and Animal Disease, Pest Control, and Animal Care program (CFDA 10.025) effective February 2, 2026. The three-year project, concluding February 1, 2029, aims to develop a comprehensive two-pronged immunoprophylactic strategy for the...
- Louisiana State University will develop and evaluate novel mucosal vaccines to protect poultry from Highly Pathogenic Avian Influenza (HPAI) H5N1 under this $1.92M Cooperative Agreement with the U.S. Department of Agriculture's Animal and Plant Health Inspection Service (APHIS), awarded February 2, 2026, under the Plant and Animal Disease, Pest Control, and Animal Care program (CFDA 10.025). The project addresses a critical national need for next-generation HPAI H5N1 vaccines that overcome...
- This $649,815 project grant award from the U.S. Department of Agriculture's National Institute of Food and Agriculture (NIFA) under the Agriculture and Food Research Initiative (AFRI) program will support research to better understand the transmission, infection, and disease mechanisms of novel H5N1 highly pathogenic avian influenza (HPAI) viruses that have devastated the poultry industry since 2021. The award to the Regents of the University of Minnesota will enable comparative studies of three...
- Federal Cooperative Agreement Summary The Animal and Plant Health Inspection Service (APHIS) awarded the University of Maryland, College Park a $1.99 million Cooperative Agreement on February 2, 2026, under the Plant and Animal Disease, Pest Control, and Animal Care program (CFDA 10.025) to develop safe, immunogenic, and efficacious non-replicating adenovirus (AD)-vectored vaccines protecting layer and broiler chickens from highly pathogenic avian influenza (HPAI) H5 clades. The three-year...
- Federal Cooperative Agreement Award Summary The University of Georgia Research Foundation received a $1,999,873 Cooperative Agreement awarded on February 2, 2026, through the U.S. Department of Agriculture's Animal and Plant Health Inspection Service (APHIS) under the Plant and Animal Disease, Pest Control, and Animal Care program (CFDA 10.025). The award, with completion targeted for February 1, 2029, funds the development of the first U.S.-approved, mass-vaccination-ready modified live virus...
- Cooperative Agreement Award Summary Kansas State University received a $2.0 million Cooperative Agreement award from the U.S. Department of Agriculture's Animal and Plant Health Inspection Service (APHIS) under the Plant and Animal Disease, Pest Control, and Animal Care program (CFDA 10.025), effective February 2, 2026, through February 1, 2029. The award funds development and validation of a novel live-attenuated H5N1 poultry vaccine based on Bovine Parainfluenza Virus Type 3, Genotype C...
- This Project Grant award of $299,985.00, provided by the U.S. Department of Agriculture's National Institute of Food and Agriculture (NIFA) under the Agriculture and Food Research Initiative (AFRI) program (CFDA 10.310), supports research to identify viral proteins that induce cell-mediated protection against avian influenza in chickens. The goal is to develop broadly protective avian influenza vaccines for poultry. The project will be conducted by the University of Maryland, College Park over a...
- Federal Cooperative Agreement Summary Colorado State University's Sponsored Programs Division received a $2,015,677 Cooperative Agreement from the U.S. Department of Agriculture's Animal and Plant Health Inspection Service (APHIS) under the Plant and Animal Disease, Pest Control, and Animal Care program (CFDA 10.025), awarded February 2, 2026, with a completion date of February 1, 2029. The award funds development of a novel vaccine to protect poultry from highly pathogenic avian influenza...
- Federal Cooperative Agreement Summary The University of Missouri System received a $1,999,129 Cooperative Agreement from the U.S. Department of Agriculture's Animal and Plant Health Inspection Service (APHIS) under the Plant and Animal Disease, Pest Control, and Animal Care program (CFDA 10.025), awarded February 2, 2026, with completion scheduled for February 1, 2029. The award supports the development and efficacy testing of novel vaccines to protect domestic poultry from Highly Pathogenic...
- This federal Project Grant award of $649,997.00, provided by the National Institute of Food and Agriculture (NIFA) under the Agriculture and Food Research Initiative (AFRI) CFDA 10.310 program, supports research to understand why and how the H5N1 avian influenza virus behaves differently in dairy cattle compared to other animals. The research aims to develop better strategies to detect, contain, and mitigate the spread of this virus in the dairy industry and protect the milk supply, food safety,...
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** AVIAN INFLUENZA POSES A SERIOUS THREAT TO GLOBAL POULTRY HEALTH AND FOOD SECURITY. CURRENT VACCINES AGAINST THE PREVALENT H9N2 SUBTYPE ARE INADEQUATE, NECESSITATING INNOVATIVE APPROACHES. OUR RESEARCH AIMS TO DEVELOP EFFECTIVE MASS VACCINATION STRATEGIES USING MODIFIED LIVE ATTENUATED VACCINES (MLVS).THIS PROJECT WILL ANALYZE THE GENETIC MAKEUP OF THE H9N2 VIRUS TO UNDERSTAND ITS EVOLUTION AND IDENTIFY KEY TARGETS FOR VACCINE DEVELOPMENT. WE WILL CREATE AND TEST IMPROVED MLVS, ENSURING THEIR SAFETY AND EFFECTIVENESS IN PREVENTING DISEASE TRANSMISSION. ADDITIONALLY, WE WILL EXAMINE HOW THESE MLVS STIMULATE THE IMMUNE SYSTEM COMPARED TO TRADITIONAL VACCINES, FOCUSING ON MUCOSAL, HUMORAL, AND CELLULAR RESPONSES.OUR FINDINGS WILL SIGNIFICANTLY ENHANCE OUR UNDERSTANDING OF THE H9N2 VIRUS AND PROVIDE VALUABLE TOOLS FOR RAPIDLY ASSESSING NEW STRAINS. THIS KNOWLEDGE WILL DIRECTLY CONTRIBUTE TO THE DEVELOPMENT OF MORE EFFECTIVE VACCINES AGAINST AVIAN INFLUENZA, NOT ONLY USING MLVS BUT ALSO OTHER VACCINE TECHNOLOGIES.THIS INNOVATIVE APPROACH IS A DEPARTURE FROM TRADITIONAL METHODS AND COULD REVOLUTIONIZE POULTRY VACCINATION. THE POTENTIAL BENEFITS EXTEND BEYOND AVIAN INFLUENZA, PAVING THE WAY FOR SIMILAR STUDIES ON OTHER RESPIRATORY VIRUSES AFFECTING POULTRY AND LIVESTOCK. BY ADDRESSING THE LIMITATIONS OF CURRENT VACCINES AND DEVELOPING SAFER, MORE EFFECTIVE ALTERNATIVES,WE CAN PROTECT ANIMAL HEALTH, SAFEGUARD THE FOOD SUPPLY, AND MITIGATE THE ECONOMIC IMPACT OF AVIAN INFLUENZA OUTBREAKS.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $650.0k | 6/12/24 |