Project Grant 20253960144635

Award Date 4/15/25
Completion Date 4/14/28
Dollars Obligated $650K
Federal Grant Program
10.310
Assistance Type
Project Grant
Place of Performance
Pittsburgh, PA 15260, USA
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This federal Project Grant award, valued at $649,992.00 and provided by the USDA National Institute of Food and Agriculture through the Agriculture and Food Research Initiative (CFDA 10.310), seeks to understand how certain bird flu viruses, particularly H5, H7, and H9 strains, can adapt to infect cattle. The research will investigate how these viruses bind to various cattle tissues, including the lungs, digestive system, and mammary glands, to assess their potential risk to livestock....
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The federal Project Grant award by the U.S. Department of Agriculture's National Institute of Food and Agriculture (USDA NIFA), through the Agriculture and Food Research Initiative (AFRI) program (CFDA 10.310), aims to understand the unique behavior of the H5N1 avian influenza virus in dairy cattle. The $649,997 award, made on April 15, 2025, supports research conducted by the University of Pittsburgh to investigate how the virus primarily affects the udder of infected cows, leading to the production of thick, contaminated milk and potential zoonotic transmission. The research utilizes advanced laboratory techniques and models to study the virus's mechanisms of spread and the host's inflammatory and antiviral responses, without the use of live animals. This work is critical to developing better strategies for detecting, controlling, and preventing future outbreaks of this virus in dairy cattle, thereby protecting the milk supply, food safety, and the agricultural economy.

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