The Department of Agriculture's National Institute of Food and Agriculture awarded Purdue University $650,000 under the Agriculture and Food Research Initiative competitive grants program to conduct research from June 2023 to May 2027 related to beef cattle production efficiency and health. Specifically, the university will analyze changes in the ruminal, intestinal, and cecal microbiome of grain-finished cattle administered tylosin and monensin antibiotics to characterize antibiotic-responsive metabolites. Researchers will also determine the host immunological response to microbial signals and integrate metagenome, metabolome, and transcriptome data to develop a comprehensive model of the gastrointestinal system. The central hypothesis is that antimicrobial drugs improve host intestinal function and integrity by inhibiting bile salt hydrolyzing bacterial species, resulting in a conjugated bile acid profile that dampens inflammation and enhances gut barrier function to decrease the immunological costs of disease. Insights gained from multiple omics techniques aim to identify alternative production management strategies that enhance efficiency, health, and welfare outcomes for feedlot cattle.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $650.0k | 4/10/23 |