Project Grant 20236701539527
- Auburn University received a $300,000 project grant awarded March 1, 2026, by the U.S. Department of Agriculture's National Institute of Food and Agriculture (NIFA) through the Agriculture and Food Research Initiative (AFRI) Foundational and Applied Science Program (CFDA 10.310). The grant supports a two-year research project extending through February 29, 2028, investigating how paternal nutritional status influences offspring development and performance in sheep as a model livestock species....
- The National Institute of Child Health and Human Development (NICHD) awarded a $160,500 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to Baylor College of Medicine. The grant will support research investigating the mechanisms for reduced sex steroid hormone synthesis in male offspring born to mothers fed a low-protein diet during pregnancy. The researchers will use a previously developed rat model of lean type 2 diabetes to study how...
- Federal Project Grant Award Summary Washington State University received a $300,000 project grant from the Institute of Food Production and Sustainability under the Agriculture and Food Research Initiative (AFRI) Foundational and Applied Science Program (CFDA 10.310) to conduct research on epigenetic modifications in cattle placental development. The award, which commenced February 1, 2026, and concludes January 31, 2028, supports fundamental research aimed at identifying parent-specific...
- The Department of Agriculture's National Institute of Food and Agriculture awarded a $120,000 Project Grant under the Agriculture and Food Research Initiative competitive grants program to Virginia Polytechnic Institute & State University from July 2021 through June 2023. The grant funds research to investigate embryonic losses occurring during blastocyst hatching and embryo elongation in cattle, which can significantly impact the cattle industry. The principal investigator will...
- This project grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research investigating placental essential fatty acid (EFA) metabolism in gestational diabetes mellitus (GDM) through integrative spatial multiomics. Awarded to Oregon Health & Science University on August 1, 2025, with total obligations of $1.512 million through April 30, 2030, the research aims to...
- Federal Grant Award Summary Texas A&M Agrilife Research received a $650,000 Project Grant from the USDA National Institute of Food and Agriculture under the Agriculture and Food Research Initiative (AFRI) program (CFDA 10.310), with an award date of February 1, 2026, and a completion date of January 31, 2029. The grant funds research to address embryonic mortality in cattle, which represents a significant economic loss to the livestock industry. The research will produce foundational...
- Federal Project Grant Award Summary Yale University received a $2.25 million Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) to conduct research on the genetic, cellular, and molecular mechanisms underlying reduced sperm motility in male infertility. The award, issued on August 8, 2025, with a completion date of April 30, 2030, will support investigator-initiated...
- Federal Project Grant Award Summary The University of California, Davis received a $128,898 project grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), awarded August 1, 2025, with completion scheduled for July 31, 2027. This award funds research investigating the three-dimensional (3D) genome-based transcriptional program governing male germline differentiation during...
- Federal Grant Award Summary Albert Einstein College of Medicine received a $151,040 Project Grant award from the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865) effective January 1, 2026, with a completion date of August 31, 2028. The research focuses on understanding the regulation of spermiogenesis—the process of sperm cell development and maturation—specifically investigating how the E3 ubiquitin...
- Federal Grant Award Summary Cornell University's Office of Sponsored Programs received a $300,000 Project Grant from the USDA National Institute of Food and Agriculture (NIFA) under the Agriculture and Food Research Initiative (AFRI) Foundational and Applied Science Program (CFDA 10.310), awarded March 1, 2026, with completion scheduled for February 29, 2028. The research project, conducted at Cornell's Ithaca, New York campus, focuses on resolving early embryonic loss in cattle by investigating...
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THE PATERNAL ORIGINS OF HEALTH AND DISEASES HAVE BEEN SUBSTANTIALLY EXPLORED IN RODENT MODELS, BUT LITTLE IS KNOWN ABOUT HOW PATERNAL DIET INFLUENCES EARLY EMBRYONIC DEVELOPMENT AND FERTILITY ACROSS MULTIPLE GENERATIONS IN LIVESTOCK. THE ULTIMATE GOAL OF THIS PROPOSAL IS TO EVALUATE PATERNAL ENVIRONMENTAL EFFECTS ON EMBRYO DEVELOPMENT AND FERTILITY OF THE OFFSPRING. IN SPECIFIC OBJECTIVE 1, WE WILL SUPPLEMENT METHIONINE (A METHYL DONOR) TO RAMS FROM WEANING TO PUBERTY. AT PUBERTY, RAMS WILL BE USED FOR BREEDING SYNCHRONIZED EWES. EMBRYOS WILL BE FLUSHED AND INVESTIGATED FOR THE EFFECTS OF PATERNAL DIET ON EMBRYO DEVELOPMENT, GENE EXPRESSION, AND DNA METHYLATION PATTERNS. IN SPECIFIC OBJECTIVE 2, WE WILL DETERMINE THE EFFECTS OF PATERNAL NUTRITION ON THE REPRODUCTIVE PERFORMANCE OF THE OFFSPRING USING 20 TWIN PAIRS OF RAMS. ONE MEMBER OF EACH OF THE 20 TWIN PAIRS WILL BE RANDOMLY SELECTED FOR METHIONINE SUPPLEMENTATION FROM WEANING UNTIL PUBERTY. THE OTHER 20 RAMS WILL BE USED AS CONTROLS. F1 AND F2 GENERATIONS WILL BE PRODUCED FROM THE TWO GROUPS OF RAMS. REPRODUCTIVE PERFORMANCE TRAITS AND SPERM QUALITY TRAITS WILL BE COLLECTED FROM F1 AND F2 GENERATIONS FOR ASSOCIATION ANALYSIS WITH THE METHIONINE SUPPLEMENTATION TO THE F0 GENERATION. THE MOLECULAR CHARACTERIZATION OF THE PATERNAL GENOMIC AND EPIGENETIC SIGNATURES CONTRIBUTING TO EMBRYO DEVELOPMENT AND REPRODUCTIVE PERFORMANCE MAY LEAD TO THE DEVELOPMENT OF BIOMARKERS OF IMPROVED REPRODUCTIVE EFFICIENCY. WE BELIEVE THIS WORK IS RELEVANT TO THE AREA PRIORITIES OF EMBRYONIC AND FETAL DEVELOPMENT AND EFFECTS OF NUTRITIONAL PLANE ON REPRODUCTIVE PERFORMANCE. THE STUDY WILL ALSO LOOK AT THE EFFECT OF THE FATHER'S DIET ON THE REPRODUCTIVE PERFORMANCE OF THEIR OFFSPRING, UP TO TWO GENERATIONS. THE RESULTS OF THE STUDY MAY LEAD TO THE DISCOVERY OF BIOMARKERS FOR IMPROVED REPRODUCTIVE EFFICIENCY IN LIVESTOCK.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $650.0k | 3/16/23 |