Project Grant 20236701140356

Award Date 6/1/23
Completion Date 5/31/26
Dollars Obligated $176K
Federal Grant Program
10.310
Assistance Type
Project Grant
Place of Performance
Bozeman, MT 59717, USA
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Montana State University received a three-year, $176,186 Project Grant award from the United States Department of Agriculture's National Institute of Food and Agriculture under the Agriculture and Food Research Initiative competitive grants program. The grant will fund research into Mycoplasma ovipneumoniae, a bacterial pathogen of sheep that can cause respiratory disease, especially when co-occurring with other pathogens such as Mannheimia haemolytica. The university researchers will investigate how biofilm formation allows the bacteria to evade the host immune system and become resistant to antibiotic treatment. Specifically, the grant-funded research will map the distribution of M. ovipneumoniae and its biofilms in the respiratory tract of sheep; determine how biofilm formation affects the bacteria's susceptibility to antibiotics; and identify the mechanisms by which biofilms impact the function of phagocytes, which are immune cells that destroy bacteria. The results of this research could help reduce M. ovipneumoniae infections in sheep herds.

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