Project Grant 1908521

This Project Grant award from the National Science Foundation's (NSF) Biological Sciences program provides $500,000 from March 2024 through February 2027 to researchers at the University of Maryland and Silvec Biologics, Inc. to develop methods to stabilize RNA genomes in viruses that can be used as therapies to treat plant diseases. The project aims to use computational approaches, including artificial intelligence, to design RNA structures that can be inserted into virus genomes to increase...

This $2.11 million project grant from the National Science Foundation's Division of Emerging Frontiers, under the Biological Sciences federal grant program (CFDA 47.074), will fund research at Emory University and the University of Tennessee from March 2023 through February 2027 to rationally design long noncoding RNAs (lncRNAs) for epigenetic signal amplification. The researchers will define the minimal features required for large-scale silencing mediated by lncRNAs, building on the...

This $999,999 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) will fund research at the Donald Danforth Plant Science Center to elucidate the mechanisms initiating de novo chromatin modification cycles in plant cells. Over three years, the award will support experiments using cutting-edge techniques to dissect the molecular triggers establishing heritable DNA methylation patterns and long-term epigenetic silencing of transposable elements and...

This $796,460 project grant from the National Science Foundation's Division of Integrative Organismal Systems and Biological Sciences program will fund research into the role of extracellular RNA in intercellular and interkingdom communication. The University of South Alabama will lead a collaborative effort between seven laboratories to advance understanding of how RNA secreted by host cells maintains healthy microbiomes in plants, insects, and humans. The researchers will test the hypothesis...

This National Science Foundation project grant award of $1,004,258 provides funding from February 1, 2022 through January 31, 2025 to support research into perinuclear positioning of active genes in Arabidopsis thaliana. The award is made under the Biological Sciences program (CFDA 47.074) to advance understanding of gene regulation principles in eukaryotes. Specifically, the Regents of the University of California, Riverside will investigate the significance and mechanisms of perinuclear gene...

This three-year, $828,217 National Science Foundation project grant supports collaborative research on RNA processing in trypanosome mitochondria at Texas A&M Agrilife Research. Funded under the Biological Sciences program (CFDA 47.074), the award will advance understanding of gene expression regulation in the single-celled parasites that cause sleeping sickness. Specifically, the award funds three objectives investigating how mRNA editing is differentially controlled across the life cycle...

This four-year, $822,736 project grant from the National Science Foundation's Division of Integrative Organismal Systems and Biological Sciences program will fund research into the role of extracellular RNA in intercellular and interkingdom communication. Led by Clemson University, the collaborative project brings together seven laboratories to advance understanding of how RNA secreted by host cells maintains healthy microbiomes in plants, insects, and humans. The researchers will investigate...

This Project Grant from the National Science Foundation's Division of Integrative Organismal Systems and Plant Genome Research Program and Plant Biotic Interactions Program, totaling $856,318, will fund research from March 1, 2023 to February 28, 2027. The grant supports a collaborative project between seven laboratories to further understanding of the role of extracellular RNA (exRNA) in intercellular and interkingdom communication. Specifically, the researchers aim to test the hypothesis...

This three-year, five-hundred twenty-three thousand four-hundred sixty-one dollar project grant from the National Science Foundation's Division of Molecular and Cellular Biosciences will fund research into RNA processing in trypanosome mitochondria. The grant was awarded to Seattle Children's Research Institute on April 1, 2022 and will be completed by March 31, 2025. The project aims to advance understanding of gene expression regulation in trypanosomes, single-celled parasites that alternate...

This federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) provides $796,823 to the University of Missouri System to conduct research on the genetic and molecular mechanisms behind meiotic silencing by unpaired DNA. The research aims to better understand how organisms use RNA-based gene silencing systems to identify and suppress the expression of DNA segments lacking a pairing partner, which can indicate the presence of viruses or...