Cooperative Agreement UG3HL173394
- This $921,009 Cooperative Agreement award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports a multi-center, randomized, double-blind, placebo-controlled trial titled "ASTRO: Adjuvant Steroid Injection Outcomes in Idiopathic Subglottic Stenosis." Led by researchers at The Johns Hopkins University, the ASTRO trial will evaluate the safety and efficacy of serial intralesional steroid injections as an adjunct treatment for...
- This Project Grant award of $153,099.00 from the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) is funding research to use target trial emulation and g-methods for causal inference from observational data to address gaps in knowledge about the care of patients with acute respiratory distress syndrome (ARDS), with a focus on evaluating dynamic treatment regimes for steroid initiation, duration, and dosing. The research will utilize data...
- This $233,250 Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports a pilot study to evaluate the use of the IL-1 receptor antagonist anakinra as an early intervention to prevent severe asthma exacerbations requiring systemic steroids. The grant recipient, the University of North Carolina at Chapel Hill, will investigate anakinra's anti-inflammatory effects and fast onset of action as a potential steroid-sparing treatment...
- This Project Grant award of $762,867.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to investigate the role of the cofilin-1 protein in regulating mitochondrial function and quality control in airway epithelial cells. The research, conducted by The Johns Hopkins University, seeks to understand how the loss of cofilin-1 impacts mitochondrial dynamics and mitophagy, and how these processes contribute to airway epithelial dysfunction in...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $288,986 to Biotherapeutics, Inc., a biotechnology company in Blacksburg, VA. The grant supports the development of a novel oral immunoregulatory therapeutic for the treatment of asthma. The key objectives are to: 1) Determine the safety profile and pharmacokinetics of the new therapeutic in rats, and 2) Characterize the therapeutic...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $771,750 to the Albert Einstein College of Medicine to conduct a cluster randomized controlled trial called "PRAGMATIC-S". The project aims to create an innovative interface between primary care and school-based programs to optimize the delivery of guideline-based asthma care to urban children with persistent or uncontrolled asthma. The award period runs...
- This $2,456,717 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) aims to exploit emerging ideas in G protein-coupled receptor biology and pharmacology to treat asthma. The award supports a highly collaborative research team at Thomas Jefferson University's Sidney Kimmel Medical College to pursue three key goals: 1) identify novel targets and targeting molecules involving G protein-coupled receptor...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) is providing $731,130 to the Children's Hospital Medical Center to conduct a study titled "Improving Medication Adherence Using an Adaptive mHealth Intervention in Adolescents with Asthma". The study aims to evaluate the effectiveness of a stepped-care mHealth intervention for improving adherence to daily inhaled corticosteroids in adolescents with asthma. The...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $370,452 to The Johns Hopkins University to conduct research on the impact of financial toxicity on health outcomes for individuals with chronic obstructive pulmonary disease (COPD). The study will use quantitative and qualitative methods to evaluate the association between financial toxicity, disability, health-related quality of life, and medication adherence in...
- This Project Grant award for $355,935 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837) supports the development of a novel, oral immunoregulatory therapeutic for the treatment of asthma. The primary objectives are to characterize the therapeutic efficacy and dosing regimen of the compound in mouse models of asthma, and to evaluate its ability to modulate immune function and suppress inflammation in human...
This Cooperative Agreement award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $1,314,743 to The Johns Hopkins University to conduct a randomized, double-blind, placebo-controlled clinical trial titled "ASTRO: Adjuvant Steroid Injection Outcomes in Idiopathic Subglottic Stenosis." The study aims to evaluate the safety and efficacy of serial intralesional steroid injections as an adjunct treatment to improve outcomes for 226 patients with idiopathic subglottic stenosis, a rare and debilitating airway condition. The research is being conducted in partnership with patient and clinician stakeholders across 10 academic medical centers, with an award period from Sep 2025 to Aug 2026. The results of this trial have the potential to identify an effective non-surgical intervention to prolong the time between necessary airway dilation procedures for this patient population.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.3m | 9/12/25 |