Cooperative Agreement UG3DA062506

Award Date 7/1/25
Completion Date 6/30/27
Dollars Obligated $2.1M
Federal Grant Program
93.279
Assistance Type
Cooperative Agreement
Place of Performance
Washington, DC, USA
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Specifically, the research will: 1) identify the optimal dose, route of administration, and redosing requirements for oxytocin to reverse acute opioid-induced respiratory depression; 2) test if oxytocin can provide additional analgesia and prevent overdose risk in a chronic pain model with daily opioid administration; 3) evaluate if chemogenetic activation of oxytocin neurons can prevent and treat opioid-induced respiratory depression; and 4) conduct two Phase 2 clinical trials to quantify the therapeutic efficacy of oxytocin in decreasing respiratory issues and pain perception in patients receiving opioids. This research aims to develop a non-opioid receptor antagonist-based approach to address the serious national opioid crisis.

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