The National Cancer Institute (NCI), under the Cancer Cause and Prevention Research program (CFDA 93.393), awarded a $398,398 Cooperative Agreement to Cold Spring Harbor Laboratory (CSHL) to discover natural products and natural product derivatives as inhibitors of KLK6 to prevent the progression of preneoplastic ductal pancreatic cancer. The 3-year award, starting July 2025, aims to: 1) perform pseudo-evolution of natural product libraries using SuFEx click chemistry to enhance efficacy and drug-like properties, 2) develop and validate cell-free assays to identify KLK6 inhibitors, and 3) validate the efficacy of non-cytotoxic natural products and derivatives as preventive agents using cell-based assays and in vivo models. This research seeks to identify natural product-based interventions that can prevent the progression of early-stage pancreatic cancer, which has a 5-year survival rate of only 13% largely due to late-stage diagnosis.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $398.4k | 7/11/25 |