Cancer screening research network - north carolina hub (csrn-NC hub)
Active Cooperative Agreement Awarded Last action
- Award ID
- UG1CA286949
- Recipient
-
University Of North Carolina At Chapel Hill UEI D3LHU66KBLD5 Part of University Of North Carolina System Office
- Awarding agency
-
National Cancer Institute
National Institutes of Health, Department of Health and Human Services
- Obligated
- $13,193,906
Award facts
- Assistance listing
- 93.399 Cancer Control
- Completion date 69% complete
- Place of performance
- Chapel Hill, NC 27599, USA
Award details come from USAspending.gov.
Description
- Abstract
- Although evidence-based cancer screening protocols exist for several common cancer types, an estimated 70% of cancer deaths are due to cancers for which no early detection test is yet available. Multi-cancer early detection tests (mcds) seek to fill this GAP using advances in cell-free DNA detection to identify multiple cancer types from a single blood draw. This new approach to cancer screening has the potential to revolutionize early detection and reduce cancer mortality. Mcds are rapidly moving toward general commercial availability, and studies are urgently needed to improve our understanding of the risks and benefits associated with these tests and how best to implement them appropriately and effectively. To address these gaps the national cancer institute seeks to create the cancer screening research network (csrn). At the university of north carolina lineberger comprehensive cancer center, we have formed a multi-disciplinary team that is highly qualified and eager to join the NCI csrn as the csrn north carolina hub (csrn NC hub). Our extensive research experience in cancer screening trials and NCI clinical trials infrastructure, and our screening research affiliations both with UNC health, our statewide health system, and with federally qualified health centers (fqhcs), demonstrates our capacity to enroll historically underrepresented communities including specifically black, hispanic, and american indian populations. Our overarching aim is to accelerate research on emerging cancer screening technologies in partnership with the csrn. In this application, we propose to (1) establish csrn NC hub infrastructure and linkages to build capacity for future, larger studies of mcds and other novel cancer screening tests; (2) enroll a diverse patient population and conduct the vanguard feasibility trial; and (3) conduct preliminary qualitative research to elicit perspectives of diverse communities regarding MCD screening. We will build a population-based, racially diverse recruitment hub in north carolina that leverages the geographic and demographic diversity of the state. For the vanguard trial, we will enroll 2000 participants from two selected UNC health sites and one fqhc, using a mix of innovative recruitment and retention methods demonstrated to be effective in our prior studies. Based on past experience, we believe the csrn NC hub is exceptionally well-positioned to support the critical csrn goal of recruiting a diverse screening- eligible population representative of the racial, ethnic, and rural/urban distribution of both NC and the US. As part of the csrn, the NC access hub will significantly contribute to the rapid evaluation of emerging cancer screening technologies and future studies of mcds and other novel screening technologies that will yield high quality evidence to inform the use of these tests in clinical practice across diverse US populations.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Amendment | $87,042 | |
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| Amendment | $783,380 | |
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| Amendment | $87,510 | |
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| Amendment | $544,248 | |
| Amendment | $544,248 | |
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| Amendment | $544,248 | |
| Amendment | $787,596 | |
| Amendment | $787,596 | |
| Amendment | $787,596 | |
| Amendment | $787,596 | |
| Amendment | $787,596 | |
| Amendment | $787,596 | |
| Amendment | $0 | |
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| Amendment | $0 | |
| Amendment | $876,146 | |
| Amendment | $876,146 | |
| Amendment | $876,146 | |
| Original award | $876,146 |
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Quick answers
Who received award UG1CA286949?
UG1CA286949 was awarded to University Of North Carolina At Chapel Hill by National Cancer Institute (National Institutes of Health) on February 15, 2024.
How much is award UG1CA286949 worth?
$13,193,906 has been obligated on UG1CA286949.
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