Cooperative Agreement U2CAG057441

This $1,011,032 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will support Amissa Inc.'s research to develop an innovative approach for early detection of Alzheimer's disease preclinical stages. The key products and services to be delivered under this 1-year award include: Assessing the relationship between health data collected from smartwatches/wearables and cognitive function in a cohort of 50 cognitively normal older adults (aged 65+) with...

This $155,000 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) aims to identify potential microRNA (miRNA) biomarkers and regulatory targets associated with early cognitive impairment and progression to Alzheimer's disease (AD). The research will leverage plasma and brain tissue samples from the Wake Forest Alzheimer's Disease Research Center and the University of Washington Alzheimer's Disease Research Center to pursue two key objectives: 1)...

This Cooperative Agreement award from the National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), will investigate proteomic biomarkers for cognitive and brain changes related to Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD). The $4,622,818 project will measure 7,000 proteins and established AD/ADRD biomarkers in the Lothian Birth Cohort 1936 (LBC1936), one of the world's best-characterized longitudinal studies. The data will...

This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $307,000 to the University of Arizona to conduct a study on the effects of early Alzheimer's disease pathogenesis on memory accuracy and precision. The key objectives of the research are to: Use a continuous report item-location associative memory task and advanced behavioral modeling to identify subtle changes in memory precision that can differentiate between healthy aging and...

The National Institute on Aging (NIA) awarded a $2,262,375 Project Grant (CFDA 93.866 - Aging Research) to the University of Massachusetts, titled "Genomics-Guided Sleep Biomarker Discovery for Early Alzheimer's Disease: A Wearables Study." The objective is to deploy wearable devices to track sleep, heart rate, and activity in an older adult cohort with elevated genetic risk for Alzheimer's disease. The project aims to develop AI approaches for digital phenotyping of Alzheimer's...

The General Hospital Corporation (MGH) Research Management Division was awarded a $458,585 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to develop a method for detecting autoantibodies against beta-amyloid in serum as a potential biomarker for Alzheimer's disease (AD). The 2-year project aims to investigate the use of small molecule compounds called CRANAD-XS to differentially tune the binding between beta-amyloid and its...

The National Institute on Aging (NIA) awarded a $885,006 Project Grant under the Aging Research federal grant program (CFDA 93.866) to Brigham & Women's Hospital Inc. to develop a smartphone-based point-of-care diagnostic system to detect Alzheimer's disease-related biomarkers (amyloid-beta, phosphorylated tau, and neurofilament light chain) in blood plasma within 30 minutes. The goal is to create an affordable, user-friendly, and accurate blood test that can be used in primary care settings...

The National Institute on Aging awarded a $2,547,870 Cooperative Agreement (U01AG082845) to Weill Medical College of Cornell University to develop and clinically translate an ultra-high resolution and upright PRISM-PET brain scanner integrated with an ultra-high resolution electromagnetic motion tracker (EMMT). The project aims to enable early detection of tau aggregation and Alzheimer's disease severity in asymptomatic individuals through PET imaging of Braak I-II brain regions using the...

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $794,981 to the University of California, San Diego (UCSD) to study the blood-brain barrier and brain microstructure as biomarkers for predicting and monitoring the risk and treatment outcomes of anti-amyloid immunotherapy for Alzheimer's disease. The research aims to: 1) evaluate how blood-brain barrier permeability and brain microstructure changes predict and correlate with the incidence of...

This $811,228 Project Grant awarded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) supports the development of the At-Home Health Station (AHS) by B.A. Maze, Inc. The AHS is a plug-and-play modular system designed to simplify digital experiences and enable remote patient monitoring for individuals with cognitive impairment and Alzheimer's disease and related dementias (ADRD). The Phase I effort will focus on usability testing and feedback to refine the...