Federated digital pathology platform for ad/adrd research and diagnostics

Ended Cooperative Agreement Awarded Last action

Award ID
U24NS133945
Recipient
Awarding agency
Obligated
$7,944,799

Award facts

Assistance listing
93.866 Aging Research
Completion date
Funding agency
National Institute on Aging National Institutes of Health, Department of Health and Human Services
Place of performance
Kentucky, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
We will connect multiple alzheimer's disease and related dementias (ad/adrd) research centers for optimized and standardized whole slide image (WSI) advanced analytics. We propose these specific aims: specific aim 1: generate a federated platform for data sharing and analysis of human digital neuropathological (DNP) slides. Specific aim 1A: develop an open-source platform to aggregate data distributed across multiple repositories into a central registry portal. This subaim will follow federated data curation, harmonization, annotation, and standardization employing fair (findable, accessible, interoperable, and reusable) principles. Specific aim 1B: develop a federated data curation and management system. This subaim provides methods to curate physical data, such as digital images, across federated sites. WSI data and metadata will be shared with private repositories and high-performance clusters. Specific aim 2: develop and demonstrate a platform for federated machine learning/artificial intelligence (ML/AI), result evaluation, and central project information, constituting a management hub for ad/adrd studies. Specific aim 2A: develop a federated data annotation and automated AI/ML processing system. This subaim provides methods for users to prepare AI-ready multimodal (wsis, metadata, demographics, etc.) datasets from distributed sources and conduct multi-site data transfer and federated training. Services and tools developed in aim 1 will be used to programmatically generate and populate user-defined AI/ML pipelines. Specific aim 2B: develop an open-source platform for the generation and review of datasets and associated models. This subaim will provide a project evaluation portal integrating cohort, dataset, and model training results in a unified interface. A public-facing model hub will provide project, data, specifications, and model data to support data sharing and analysis requirements. To optimize and demonstrate the strengths of the novel federated network, five integrated projects are proposed. These will span a diverse sampling of human populations and diseases to leverage the unique strengths of DNP. The following sites will contribute resources, expertise, experimental study design, data, and analyses: university of kentucky (PIS nelson and bumgardner, CO-is cheung and fardo). Generate standardized sops useful for DNP diagnoses and research along with ML/AI expertise for a federated network. Northwestern/NUN study and utsa universities (PI flanagan). A focus on TDP-43 proteinopathy in community-based cohorts and ethno-racially diverse populations. Universityof SÃO paulo and ucsf (CO-i suemoto and OSC grinberg). Evaluate adnc from the brains of individuals with african and non-african ancestries. University of toronto (CO-i kovacs): use ML to study white matter TAU pathologic changes for novel insights into multiple tauopathies. University of washington (CO-i keene): study TAU pathologies across ages and environmental exposures with a focus on traumatic brain injuries.

Transactions

Action Obligated Date
Amendment $0
Amendment $3,082,904
Amendment $3,082,904
Original award $1,778,991

Subawards

Subrecipient Amount Awarded
University Of Washington Dr. Keene leads the BRalN lab which supports neuropathology for critical ADRD prospective cohort studies, particularly those focused on the long term… $73,116
Fundacao Faculdade De Medicina Dr. Claudia Suemoto (Co-I) is Associate Professor of Geriatrics, and point-person for the Brazilian Brain Bank and University of São Paulo Medical School.… $53,784
University Of Washington Dr. Keene leads the BRaIN lab which supports neuropathology for critical ADRD prospective cohort studies, particularly those focused on the long term… $71,886
The University Of Texas Health Science Center At San Antonio Dr. Flanagan, Neuropathology Core Leader of the federally funded South Texas Alzheimer’s disease research center and Director of the Nun Study, will be… $185,087
The University Of Texas Health Science Center At San Antonio $0
University Health Network Dr. Kovacs and Dr. Forrest will be involved in the neuropathological evaluation of individuals with various tauopathies and additionally ageing brains. This… $54,000

Quick answers

Who received award U24NS133945?

U24NS133945 was awarded to The University Of Kentucky Research Foundation by National Institute of Neurological Disorders and Stroke (National Institutes of Health) on September 20, 2023.

How much is award U24NS133945 worth?

$7,944,799 has been obligated on U24NS133945.

Which agency awarded U24NS133945?

National Institute of Neurological Disorders and Stroke (National Institutes of Health) awarded U24NS133945, with funding from National Institute on Aging (National Institutes of Health).

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