Mechanisms of immune protection against respiratory viruses
Active Cooperative Agreement Awarded Last action
- Award ID
- U19AI181103
- Recipient
-
The Washington University UEI L6NFUM28LQM5
- Awarding agency
-
National Institute of Allergy and Infectious Diseases
National Institutes of Health, Department of Health and Human Services
- Obligated
- $7,141,050
Award facts
- Assistance listing
- 93.855 Allergy and Infectious Diseases Research
- Completion date 45% complete
- Place of performance
- St. Louis, MO 63110, USA
Award details come from USAspending.gov.
Description
- Abstract
- Overall the sars-COV-2 pandemic highlighted the urgent need for better understanding of the mechanisms controlling broadly protective immune responses to rapidly evolving viral pathogens and generating vaccine candidates able to elicit such responses. The washington university cooperative center on human immunology (washu- cchi) application (mechanisms of immune protection against respiratory viruses) proposes a comprehensive research plan towards two main goals: (a) defining the mechanisms of germinal center persistence after vaccination in humans and how germinal center dynamics impact engagement of DE novo b cells and generation of robust CD4+ t cell, long-lived memory b cell, and bone marrow plasma cell responses (project 1); (b) determining the functional caliber of systemic and mucosal immune responses to vaccines and infection and how these impact durability, breadth, and protection (project 2). Three cores will synergize with the two research projects to support the successful completion of the research aims. The administrative core (core a) will manage the consortium, coordinate cross-project activities, and create the structure and environment needed to accomplish washu-cchi's goals. The clinical core (core b) will provide the clinical and statistical expertise to support the design and conduct of the human subjects' research studies conducted under projects 1 and 2. The proteomics core (core c) will capitalize on an array of unique technologies for the interrogation of the circulating antibody protein and b cell repertoires in samples collected under projects 1 and 2. The integrated and synergistic activities across these projects and cores will drive the successful completion of the washu-cchi's ambitious research agenda, enabling achievement of our long-term goals of providing key insights on human immune responses and informing evaluation of new mucosal vaccines targeting the human respiratory tract against existing and emerging respiratory viral pathogens.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $2,380,350 | |
| Amendment | $2,380,350 | |
| Amendment | $0 | |
| Original award | $2,380,350 |
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| University Of Texas At Austin | $251,770 | |
| The General Hospital Corporation | $194,751 | |
| The Regents Of The University Of California | $100,000 | |
| The Leland Stanford Junior University | $220,562 | |
| Fred Hutchinson Cancer Center | $212,244 | |
| Fred Hutchinson Cancer Center | $215,216 | |
| The General Hospital Corporation | $197,477 | |
| The Leland Stanford Junior University | $222,332 | |
| The Regents Of The University Of California | $113,485 | |
| University Of Texas At Austin | $255,298 | |
| University Of Texas At Austin | $170,579 | |
| The Leland Stanford Junior University | $183,815 | |
| The General Hospital Corporation | $170,579 | |
| The Regents Of The University Of California | $110,291 | |
| The Chancellor, Masters, And Scholars Of The University Of Cambridge | $41,229 | |
| ST Jude Children's Research Hospital Inc. | $178,171 |
Show all 16
Quick answers
Who received award U19AI181103?
U19AI181103 was awarded to The Washington University by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on September 4, 2024.
How much is award U19AI181103 worth?
$7,141,050 has been obligated on U19AI181103.
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