2/1 - mongolian center for environmental & occupational health - mongolia
Active Cooperative Agreement Awarded Last action
- Award ID
- U01TW012229
- Recipient
-
Mongolian National University Of Medical Sciences UEI C7V2MJADKHF9
- Awarding agency
-
Fogarty International Center
National Institutes of Health, Department of Health and Human Services
- Obligated
- $1,867,720
Award facts
- Assistance listing
- 93.113 Environmental Health
- Completion date 93% complete
- Funding
-
- $1,689,842.00 Federal
- $177,878.00 Non-federal
- Place of performance
- Mongolia
Award details come from USAspending.gov.
Description
- Abstract
- In recent decades, mongolia has experienced major economic and environmental changes, and suffered from severe air pollution. Ulaanbaatar (UB) and darkhan city (DC) have some of the highest ambient particulate matter (PM) concentrations in the world and frequently suffer epidemics of viral respiratory diseases. The associations between PM exposure and cardiorespiratory mortality and morbidity have been well documented, with an established 6.67 million premature deaths globally attributed to air pollution in 2019. Recently, attention has increased regarding the association of PM pollution and respiratory viral infection. Hence, this U01 proposal, as part of the mongolian geohealth hub program, focuses on studying the relationships and interactions between PM exposure and respiratory viral infections. The U01 project consists of a main study and two pilot studies to begin center activities. The main project is designed to test the hypothesis that PM exposure weakens the immune defense against respiratory viral infection. IT has three interconnected specific aims. Aim 1 is to characterize the relationship between PM exposure and respiratory viral infection through a time-series analysis of weekly influenza-like illness (ILI) rates in association with PM levels within and across UB and DC, adjusting for potential confounders and CO-pollutants. As an air pollution control measure, UB started the implementation of processed coal use in may, 2019, whereas DC continues to use raw coal. Nesting this policy intervention into the time-series analysis strengthens the causal inference of the PM-ILI association derived from natural variabilities over time. Aim 2 is to examine immunologic and viral responses to personal PM exposure through two parallel panel studies in residents of UB and DC, respectively. Each panel consists of 100-120 nonsmoking adults who will be measured semiannually during a 3-year follow-up period. ILI counts and immunologic biomarkers will be associated with personal PM exposures. Aim 3 is to define the direct effects of PM exposure on epithelial integrity and immune signaling and the subsequent impact on anti-viral responses. This will be achieved through cell culture studies that are directly linked to aim 2 subjects (as cell donors). The two pilot studies, built upon the aim 2 main study, aim to explore the effects of PM on pulmonary tuberculosis and bone mineral loss, respectively. These studies are motivated by high prevalence of both tuberculosis and osteoporosis in mongolia and by emerging evidence suggesting PM or heavy metals in PM as risk factors. This U01 proposal is an interdisciplinary research project involving researchers in epidemiology, toxicology, environmental and occupational health, exposure science, biostatistics, virology, immunology, environmental engineering, respiratory medicine, and infectious disease from multiple institutions in mongolia, duke university, and duke kunshan university. The U01 research is designed to be the initial main platform for engaging U2R fellows (trainees) and faculty (mentors) in research and training. 1
Transactions
| Action | Federal | Non-federal | Date |
|---|---|---|---|
| Amendment | $111,174 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $177,878 | $0 | |
| Amendment | $177,878 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $111,174 | $0 | |
| Amendment | $177,878 | $0 | |
| Amendment | $177,878 | $0 | |
| Amendment | $177,878 | $0 | |
| Amendment | $111,174 | $0 | |
| Amendment | $177,878 | $0 | |
| Amendment | $111,174 | $0 | |
| Original award | $177,878 | $177,878 |
Show all 15
Quick answers
Who received award U01TW012229?
U01TW012229 was awarded to Mongolian National University Of Medical Sciences by Fogarty International Center (National Institutes of Health) on June 13, 2022.
How much is award U01TW012229 worth?
$1,867,720 has been obligated on U01TW012229: $1,689,842 in federal funding and $177,878 in non-federal funding.
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