A mechanistic 3D AI-powered map of genetic child

Active Cooperative Agreement Awarded Last action

Award ID
U01HL175383
Recipient
Awarding agency
Obligated
$2,391,450

Award facts

Assistance listing
93.837 Cardiovascular Diseases Research
Completion date 43% complete
Place of performance
Cincinnati, OH 45229, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
/summary leveraging the technologies and infrastructure in our previous lungmap phases, we will construct a multi-scale map of developing acinar and alveolar structures during normal childhood and in the setting of childhood interstitial lung disease (child) characterized by aberrant lung morphogenesis. Linked to gene variants, child provides a unique opportunity to understand key genetic pathways and cellular interactions of human acinar and alveolar development, in turn informing injury-repair associated with lung diseases throughout the lifespan. Working in a collaborative LUNGMAP3 consortium, including other research centers, the data coordinating center (DCC), the human tissue core (HTC), our LUNGMAP3 project will use single-cell and spatial multiomics, high-resolution confocal and electron microscopy, patient-derived ipscs, and bioinformatics including AI tools to define, model, and predict normal and diseased lung development. The resulting mechanistic insights and enabling technologies will be disseminated to the entire lung community via disease atlases and web portals, as we have done during LUNGMAP1 and 2, to accelerate lung biology discoveries and disease therapies.

Transactions

Action Obligated Date
Amendment $786,450
Amendment $802,500
Original award $802,500

Quick answers

Who received award U01HL175383?

U01HL175383 was awarded to Childrens Hospital Medical Center by National Heart Lung and Blood Institute (National Institutes of Health) on September 1, 2024.

How much is award U01HL175383 worth?

$2,391,450 has been obligated on U01HL175383.

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