Neurocognitive effects of type 1 diabetes in young children: indiana university clinical center

Active Cooperative Agreement Awarded Last action

Award ID
U01DK140782
Recipient
Awarding agency
Obligated
$1,298,217

Award facts

Completion date 45% complete
Place of performance
Indianapolis, IN 46202, USA

Award details come from USAspending.gov.

Description

Abstract
Many individuals living with type 1 diabetes (T1D) experience significant cognitive impairments. These impairments are more common in people diagnosed in early childhood, particularly under 5-6 years of age, and are associated with measurable neuropathologic brain structure changes. Across the lifespan, these cognitive difficulties can impact adaptive functioning, academic performance, and disease management. Strategies to decrease the likelihood of cognitive deficit development are needed. The study we propose in this application is designed to address current gaps in our knowledge regarding the underpinnings of neurocognitive changes in persons living with diabetes. We anticipate that IT would be implemented by a multicenter collaborative effort of pediatric endocrinologists, psychologist, and radiologists whose ultimate goals are to: 1) better understand the impact of T1D on the developing brain; 2) identify and evaluate potential risk and protective factors associated with T1D-related neurocognitive impact; and 3) assess potential associations between use of newer and emerging diabetes management technologies and neurocognitive functioning among children with T1D. With this application we propose two aims to achieve these goals: firstly, we propose to characterize associations of cognitive function and brain structure with clinical and environmental parameters in children with T1D enrolled at 6-

Transactions

Action Obligated Date
Amendment $511,824
Amendment $0
Amendment $0
Amendment $515,461
Original award $270,932

Quick answers

Who received award U01DK140782?

U01DK140782 was awarded to Trustees Of Indiana University by National Institute of Diabetes and Digestive and Kidney Diseases (National Institutes of Health) on August 15, 2024.

How much is award U01DK140782 worth?

$1,298,217 has been obligated on U01DK140782.

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