Determinants of neurocognitive complications in T1D
Active Cooperative Agreement Awarded Last action
- Award ID
- U01DK140735
- Recipient
-
The Regents Of The University Of Colorado UEI MW8JHK6ZYEX8 Part of The Regents Of The University Of Colorado
- Awarding agency
-
National Institute of Diabetes and Digestive and Kidney Diseases
National Institutes of Health, Department of Health and Human Services
- Obligated
- $1,394,495
Award facts
- Assistance listing
- 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research
- Completion date 45% complete
- Place of performance
- Aurora, CO 80045, USA
Award details come from USAspending.gov.
Description
- Abstract
- Children with type 1 diabetes (T1D) suffer from subtle cognitive impairments and structural alterations in the brain. These impairments progress with age and may eventually lead to increased difficulty managing the disease, resulting in worsening glycemic control, potentially life-threatening complications, and reductions in quality of life. Causes of cognitive decline in T1D are not well understood. Episodes of hypoglycemia, chronic hyperglycemia, glycemic variability and diabetic ketoacidosis (DKA) have all been suggested to play roles. Our team at the university of colorado proposes to join a multicenter NIH consortium to investigate the impact of T1D on neurocognitive and psychosocial functioning in pre-pubertal children. We propose collaborative development of the study protocol, enrollment of a representative study population, and prospective follow-up to collect exposure and outcomes data for hypothesis testing. This study will further elucidate the role of DKA, chronic hyperglycemia, severe hypoglycemia and established or emerging treatment modalities on neurocognitive and psychosocial functioning of pre-pubertal children followed for up to three years after T1D diagnosis. We propose to test the following hypotheses: H1: DKA at diagnosis of T1D has a detrimental long-term effect on neurocognitive and psychosocial functioning (including full scale IQ), independent of SEX, race/ethnicity, and socioeconomic status. H2: chronic hyperglycemia exposure, assessed by repeatedly measured HBA1C or CGM time above range (TAR >250), has a detrimental long-term effect on neurocognitive and psychosocial functioning, independently of SEX, race/ethnicity, and socioeconomic status of the child. H3: recurrent severe hypoglycemia or excessive time below range (TBR
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $561,524 | |
| Amendment | $0 | |
| Amendment | $561,586 | |
| Original award | $271,385 |
Quick answers
Who received award U01DK140735?
U01DK140735 was awarded to The Regents Of The University Of Colorado by National Institute of Diabetes and Digestive and Kidney Diseases (National Institutes of Health) on August 15, 2024.
How much is award U01DK140735 worth?
$1,394,495 has been obligated on U01DK140735.
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