Cooperative Agreement U01DE034198

Award Date 9/20/24
Completion Date 6/30/28
Dollars Obligated $549K
Funding Federal Agency
Office of the Director
Federal Grant Program
93.310
Assistance Type
Cooperative Agreement
Place of Performance
Davis, CA, USA
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  1. Optimize laboratory methods for recovering and quantifying RNA and DNA viruses from human stool samples, addressing interests in viral isolation, detection, quantification, enrichment, and eliminating environmental contamination.

  2. Comparatively evaluate stool viromics techniques by applying them to a longitudinal human cohort, assessing DNA/RNA viromics and other omics methods to capture viral dynamics and develop computational approaches to enable meta-analyses across studies.

  3. Extend the techniques to diverse low-biomass human sample types, in consultation with the broader Human Virome Project (HVP) consortium.

The total funding amount is $548,659, awarded to the University of California, Davis. A sub-award of unspecified amount is provided to the University of Colorado, Boulder to lead computational analysis efforts, including developing models for enhanced metagenomic virus detection, software for viral quantification, and high-resolution metagenomic analyses. The project is scheduled to run from September 2024 through June 2028.

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