Concentration and single virion analysis of the virome
Active Cooperative Agreement Awarded Last action
- Award ID
- U01DE034179
- Recipient
-
University Of North Carolina At Chapel Hill UEI D3LHU66KBLD5 Part of University Of North Carolina System Office
- Awarding agency
-
National Institute of Dental and Craniofacial Research
National Institutes of Health, Department of Health and Human Services
- Obligated
- $233,251
Award facts
- Assistance listing
- 93.121 Oral Diseases and Disorders Research
- Completion date 55% complete
- Funding agency
- Office of the Director National Institutes of Health, Department of Health and Human Services
- Place of performance
- Chapel Hill, NC 27599, USA
Award details come from USAspending.gov.
Description
- Abstract
- Clinical virology is predicated on the workflow of analyzing small sample volumes (to minimize patient discomfort, storage, and fit legacy infrastructure) for a single analyte, i.e., virus, with utmost precision. The human virome project (HVP) does not share these restrictions. The HVP priority tissues of urine, stool, saliva, and blood can be acquired from healthy people in a 50 - 500 ML sample size. For instance, the red cross makes normal plasma available in 500 ML bags, and NGS allows for the characterization of all human viruses in a single reaction. This proposal responds to RFA-RM-23-018 with the development of two novel tools: aim 1, a virus purification pipeline that utilizes larger volumes to achieve < 1 genome copy/ ML sensitivity; aim 2, a single virion detection pipeline to provide an accurate denominator of how many intact virions a given NGS sequence set is representing. We hypothesize that viral direct counts (VDC) akin to bacterial direct counts will become the essential parameter for integrating the studies in the HVP.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $1 | |
| Amendment | $0 | |
| Amendment | $233,249 | |
| Original award | $1 |
Quick answers
Who received award U01DE034179?
U01DE034179 was awarded to University Of North Carolina At Chapel Hill by National Institute of Dental and Craniofacial Research (National Institutes of Health) on September 20, 2024.
How much is award U01DE034179 worth?
$233,251 has been obligated on U01DE034179.
Which agency awarded U01DE034179?
National Institute of Dental and Craniofacial Research (National Institutes of Health) awarded U01DE034179, with funding from Office of the Director (National Institutes of Health).
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