This $11,811,988 Cooperative Agreement award from the National Institute on Drug Abuse (NIDA), under the CFDA 93.279 Drug Use and Addiction Research Programs, supports the development of the novel mu-opioid receptor antagonist methocinnamox (MCAM) for preventing opioid relapse and overdose. The award to the University of Texas Health Science Center at San Antonio aims to: 1) submit an Investigational New Drug (IND) application for MCAM, 2) complete Phase 1 and 1b clinical trials, 3) plan a Phase 2 trial, and 4) conduct additional non-clinical toxicology studies as recommended by the FDA. If successful, this project would fill an unmet need for an orally bioavailable, long-acting medication to prevent opioid relapse after detoxification, with potential additional indications for preventing and reversing opioid overdose.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $3.9m | 5/2/25 | ||
| Not listed | $3.9m | 8/6/24 | ||
| Not listed | $3.9m | 8/6/24 |