Cooperative Agreement U01CA283753
- This Cooperative Agreement award of $922,755.00 from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) supports research at the University of Massachusetts Medical School (UMASS Medical) aimed at understanding the role of tRNA modification and translational remodeling in cancer progression and metastasis. The project will use advanced RNA mass spectrometry, sequencing, and ribosome profiling techniques to comprehensively catalog tRNA modification dynamics...
- This Cooperative Agreement award for $639,882, funded by the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396), supports research at the University of North Carolina at Chapel Hill to elucidate the molecular mechanisms of metastasis organ tropism in breast cancer. The key objectives are to: Identify molecular determinants of lung and liver organ-specific metastasis using a comprehensive dataset of human primary tumors and metastases, as well as genetically...
- This Cooperative Agreement award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $953,922.00 in funding to the Scripps Research Institute in California to conduct research on the links between RNA modifications, codon use, translation, and metabolism in cancer cells. The overall goal is to identify correlations between modification states of the translation apparatus and changes in codon occupancy and translation rate across cancer cell lines, particularly...
- This Cooperative Agreement awarded by the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $1,281,520.00 in funding to The Leland Stanford Junior University to conduct research on the fundamental biological mechanisms of cancer metastasis, organ tropism, and immune evasion. The project aims to integrate genetic barcoding with single-cell profiling to uncover the key molecular drivers underlying metastatic fitness and diverse cancer cell states in pancreatic ductal...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to elucidate the underlying molecular mechanisms of cellular mechanosensitivity. The $387,662 award to Duke University will enable the development of novel biosensors and techniques to investigate how mechanical forces and protein phosphorylation regulate the mechanical state and force transmission capabilities of key linker...
- This federal Project Grant award from the National Cancer Institute (NCI) under CFDA 93.396 (Cancer Biology Research) provides $182,755 to Cold Spring Harbor Laboratory (CSHL) to conduct research on genetic technology development for understanding lineage plasticity mechanisms in cancer. The award began on August 21, 2025 and is scheduled for completion on July 31, 2030. The key products and services to be delivered through this grant include: 1) developing a CRISPR screening methodology for...
- This $941,798 Cooperative Agreement was awarded by the National Cancer Institute (CFDA 93.396 Cancer Biology Research) to the Beckman Research Institute of the City of Hope, a nonprofit medical research organization in California. The funding supports research to investigate the molecular mechanisms of codon-biased translation, a process that cancer cells hijack to promote their survival and therapeutic resistance. Specifically, the project will explore the role of the ALKBH1 enzyme in...
- This $204,027 federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) is supporting the Weill Medical College of Cornell University in expanding single-cell and spatial technologies to link clonal genotypes with phenotypes during cancer evolution. The grant aims to develop advanced single-cell methods that can capture multiple data modalities, including genotypes, transcriptomes, methylomes, and protein expression, to better understand how somatic...
- The National Cancer Institute (CFDA 93.398 Cancer Research Manpower) awarded a $147,486 Project Grant to the Sloan-Kettering Institute for Cancer Research to support a 3-year research training program in cellular immunology and mechanobiology. The program aims to examine how the mechanical properties of the tumor microenvironment influence metastatic site preference and immune system response. Key research activities include in vivo modeling, biophysical measurements, and single-cell analysis to...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $541,967 to the University of Chicago to investigate the mechanical behaviors of cells and their impact on physiological processes and diseases. The research aims to expand the understanding of adherent cell mechanics and mechanobiology, focusing on the force-sensitive remodeling of cell-cell adhesions and the role of LIM...
This Cooperative Agreement award of $556,865.00 was provided by the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) to the Trustees of Tufts College to conduct research on "Stiffness-Mediated Genetic Selection of Cells". The project aims to investigate how the mechanical properties of a cell's substrate can drive the evolution of cell phenotypes and genotypes over sustained culture periods. The research will quantify how cell behaviors like growth, motility, and metastasis change as cells are cultured on soft versus stiff hydrogels, sequence genomic changes during this process, and explore how to manipulate the link between mechanosensing and phenotypic outcomes. The award period runs from September 1, 2025 to August 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $556.9k | 8/19/25 |