Cooperative Agreement U01AI201086
- The National Institute of Allergy and Infectious Diseases awarded Dartmouth-Hitchcock Clinic $232,500 on February 9, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop and deploy multiplexed reporter platforms for mapping interactions between bile acid pools and nuclear receptors. The funded work builds multiplex nuclear receptor reporter systems capable of identifying ligand-receptor binding across all 48 human nuclear receptors using physiologically...
- The National Institute of Allergy and Infectious Diseases awarded Dartmouth-Hitchcock Clinic $443,825 on August 11, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the functional role of the skin mycobiome in atopic dermatitis, particularly head and neck disease subtype. The research addresses a critical gap in understanding how fungal communities contribute to atopic dermatitis pathogenesis. While bacterial microbiome dysbiosis in atopic...
- The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services National Institutes of Health, awarded Trustees of Dartmouth College $717,139 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop a computational platform identifying clinically effective T-cell receptors (TCRs) for infectious diseases based on receptor sequences provided by users. The platform identifies TCRs putatively capable of...
- The National Institute of Allergy and Infectious Diseases awarded Trustees of Dartmouth College $458,854 on August 4, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop genome-scale fluxomics technology for measuring metabolic reprogramming in human pathogens during infection. The project addresses two barriers to routine genome-scale application of fluxomics: the labor-intensive manual data processing demanded by current isotope-tracing workflows and the...
- The National Institute of Allergy and Infectious Diseases awarded The Pennsylvania State University $113,853 on December 12, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate polymicrobial interactions in bile acid metabolism by the gut microbiome. The research decodes cross-species metabolic pathways through which gut bacteria convert host-derived primary bile acids into secondary bile acids, including 7a-dehydroxylated deoxycholic acid and...
- The National Institute of Allergy and Infectious Diseases awarded Trustees of Dartmouth College $100,228 on November 19, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate G-protein signaling mechanisms in Aspergillus fumigatus colony morphology and aerobic glycolysis. The research employs CRISPR-Cas9 genetic techniques to explore epistatic relationships between BAFA, GPAA, G-protein coupled receptors, and H-morph colony morphology in the pathogenic...
- The National Institute of Allergy and Infectious Diseases awarded The Johns Hopkins University $700,997 on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate immune homeostasis during Borrelia burgdorferi infection. The research defines the impact of BB infection-induced changes in gastrointestinal barrier function and microbiota on immune system health. The project tests the hypothesis that BB infection-induced gut barrier dysfunction,...
- The National Institute of Allergy and Infectious Diseases awarded a Cooperative Agreement totaling $581,915 to Weill Medical College of Cornell University on July 21, 2026, to investigate novel innate lymphocyte pathways controlling mucosal immunity under the Allergy and Infectious Diseases Research program (CFDA 93.855). The recipient will identify and characterize two previously unappreciated cell-intrinsic pathways that control innate lymphocyte biology and mucosal immune responses, with...
- The National Institute of Allergy and Infectious Diseases awarded Brigham & Women's Hospital Inc. $778,143 on June 3, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the regulation of polyreactive B cell repertoires in naive follicular B cells. The research addresses how microbial symbionts influence the composition and polyreactivity of the B cell repertoire, with particular focus on tolerance mechanisms that filter polyreactive and autoreactive...
- The National Institute of Allergy and Infectious Diseases awarded Trustees of Dartmouth College $158,190 on December 20, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate dual functions of an effector immunity protein in Pseudomonas aeruginosa biofilm biogenesis. The research tests the hypothesis that TSIT, a Type VI secretion system immunity protein in P. aeruginosa, functions as both a traditional T6SS immunity protein and as a transcription factor...
The National Institute of Allergy and Infectious Diseases awarded Dartmouth-Hitchcock Clinic a cooperative agreement of $561,873 on July 24, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on bile acid control of commensal-specific immune responses. The funded research investigates how bile acids—gastrointestinal metabolites with dual roles in lipid absorption and cell signaling—dynamically engage nuclear receptors and GPCRs to modulate mucosal immune cell function and inflammation. The project examines how bile acid pools are remodeled during commensal organism colonization, specifically investigating segmented filamentous bacteria (SFB) colonization in the ileum and its effects on anti-inflammatory TH17 cell induction and interleukin-10 production. The research maps novel and competitive bile acid–nuclear receptor interactions that occur at physiological bile acid concentrations in the ileum and become dysregulated during Crohn's disease-like ileitis, with the goal of tuning activities of immunoregulatory nuclear receptors. The team employs quantification and manipulation tools for enterohepatic bile acid pools in vitro and in vivo. Work is performed in Lebanon, New Hampshire. The period of performance extends from July 24, 2026, through May 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $561.9k | 7/23/26 |