Hipc data coordinating center

Active Cooperative Agreement Awarded Last action

Award ID
U01AI167892
Recipient
Awarding agency
Obligated
$74,668,111

Award facts

Assistance listing
93.855 Allergy and Infectious Diseases Research
Completion date 91% complete
Place of performance
La Jolla, CA 92037, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
The human immunology project consortium (hipc) was founded in 2010 to create a network of independent centers focused on measuring human immune responses with high-throughput systems immunology approaches coupled with detailed clinical phenotyping. We propose to develop a hipc coordinating center (HCC) that will provide data more rapidly and effectively to the broader scientific community, and also serve the entire hipc by increasing the value of the research performed at hipc centers. In parallel, the HCC will serve as a promoter of cross-hipc collaborations through the organization of multi-center analysis projects and a centralized portal to provide a space for the exchange of ideas. Specifically, the HCC will continue the development of shared data standards, provide a central knowledgebase of study results, establish tools to visualize and analyze data, lead synergistic cross-center analysis efforts, provide a portal to make the tools and data broadly accessible, and provide administrative support for the activities of hipc subcommittees and management of the infrastructure and opportunity fund (IOF) program. Our team has proven experience in running programs of similar scale and complexity. We also have the necessary familiarity with the hipc network, with our team including current PIS of the data standards IOF project, the signatures IOF project, clinical information capture, and the existing immunespace data portal. This proposal leverages this combined experience and infrastructure while, in parallel, implementing various significant and necessary improvements facilitated by the tighter integration and the 5-year time horizon of this dedicated HCC grant.

Transactions

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Amendment Hipc data coordinating center - supplement project summary/abstract the proposed work in this project will be a continuation of the duties previously… $469,233
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Amendment $25,547
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Amendment Hipc data coordinating center - supplement project summary/abstract the proposed work in this project will be a continuation of the duties previously… $25,547
Amendment $25,547
Amendment $25,547
Amendment $445,252
Amendment $445,252
Amendment Hipc data coordinating center - supplement project summary/abstract the proposed work in this project will be a continuation of the duties previously… $445,252
Amendment $445,252
Amendment Hipc data coordinating center - supplement project summary/abstract the proposed work in this project will be a continuation of the duties previously… $445,252
Amendment $445,252
Amendment $3,018,229
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Amendment $3,018,229
Amendment Hipc data coordinating center - supplement project summary/abstract the proposed work in this project will be a continuation of the duties previously… $3,018,229
Amendment $3,018,229
Amendment $3,018,229
Amendment Hipc data coordinating center - supplement project summary/abstract the proposed work in this project will be a continuation of the duties previously… $3,018,229
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Latest 50 listed here. See the rest on GovTribe.

Subawards

Subrecipient Amount Awarded
Duke University This project aims to extend cytoGPNet, our recently developed deep Gaussian process framework for single-cell data analysis, to jointly model single-cell and… $160,946
Icahn School Of Medicine At Mount Sinai The ongoing identification of immune “signatures” that associate with outcomes of both vaccinations and natural infections is a central goal of the Human… $76,050
The Leland Stanford Junior University We will leverage data and samples of two independent clinical trials taking place in East Africa. MICDROP in Uganda and PROSYNK in Kenya. Both studies… $105,850
Yale Univ As with many aspects of human health, genetic diversity has been shown to be a major contributor to immune system heterogeneity. However, the functional… $67,000
Yale Univ The ongoing identification of immune “signatures” that associate with outcomes of both vaccinations and natural infections is a central goal of the Human… $75,375
Massachusetts Institute Of Technology The Lauffenburger laboratory will undertake computational multi-variate data analysis employing machine learning modeling of complex multi-variate relationships… $71,550
Childrens Hospital Medical Center Genetic variation plays a critical role in shaping the diversity of human immune responses, yet the functional consequences of most immune-related genetic… $48,150
Childrens Hospital Medical Center Objectives: The goals of this contract will be to assist in achieving the aims of the HIPC-III Signatures IOF, which will include 1) Expansion of the Immune… $72,224
Yale Univ Dr. Steven Kleinstein will oversee the work being carried out at Yale as part of this project. This work will include: • Organization of three cross-HIPC… $630,066
Seattle Children's Hospital The HIPC Immune Signatures Data Resource will be expanded with new vaccine and infection studies as well as new data from single cell RNA-seq. We will… $88,605
The Trustees Of Columbia University In The City Of New York As part of the HIPC-II Signatures Project, we created the "HIPC Signatures Dashboard", which enables easy navigation of immune signatures and use by a range… $74,025
Benaroya Research Institute At Virginia Mason Dr. Altman and his senior bioinformatician, Naresh Doni Jayavelu, will lead the HIPC “Signatures” IOF project. Specifically, they will coordinate among all HIPC… $80,100
Benaroya Research Institute At Virginia Mason Dr. Altman and his senior bioinformatician, Naresh Doni Jayavelu, will lead the HIPC “Genotype” IOF project. Specifically, they will coordinate among all HIPC… $51,990
Emory University 1) Provide the HCC team with expert input on Portal features (e.g. data visualizations) and data standards from a clinician's perspective 2) Help and train… $39,125
The Leland Stanford Junior University The recent COVID epidemic highlighted the importance of vaccination in public health, however not everyone responds to vaccines equally. Adverse childhood… $131,191
Yale Univ Genotype Analysis As with many aspects of human health, genetic diversity has been shown to be a major contributor to immune system heterogeneity. However,… $76,147
Yale Univ Dr. Steven Kleinstein will oversee the work being carried out at Yale as part of this project. This work will include: • Organization of three cross-HIPC… $622,028
The Trustees Of The University Of Pennsylvania T cells play a crucial role in both infection and vaccination response. The biophysical properties of the T cell receptor (TCR), such as affinity, on-rate,… $111,753
Childrens Hospital Medical Center Genetic variation plays a critical role in shaping the diversity of human immune responses, yet the functional consequences of most immune-related genetic… $72,647
The Trustees Of Columbia University In The City Of New York Provide primary human T cells from lymphoid tissues needed for the proposed biophysical study of TCR. $30,391
Benaroya Research Institute At Virginia Mason Dr. Altman and his senior bioinformatician, Naresh Doni Jayavelu, will lead the HIPC “Genotype” IOF project. Specifically, they will coordinate among all HIPC… $79,047
Yale Univ The proposed work will develop a prototype multi-agent AI system to test the reproducibility of immune signatures (involving genes, proteins or metabolites)… $414,310
Childrens Hospital Medical Center Objectives: The goals of this contract will be to assist in achieving the aims of the HIPC-III Signatures IOF, which will include 1) Expansion of the Immune… $69,374
Massachusetts Institute Of Technology The Lauffenburger laboratory will undertake computational multi-variate data analysis employing machine learning modeling of complex multi-variate relationships… $68,699
Seattle Children's Hospital The HIPC Immune Signatures Data Resource will be expanded with new vaccine and infection studies as well as new data from single cell RNA-seq. We will… $85,754
Yale Univ Identification, standardization, and dissemination of HIPC immune signatures The ongoing identification of immune “signatures” that associate with outcomes of… $72,524
Icahn School Of Medicine At Mount Sinai Dr. Mayte Suarez-Farinas is Associate Professor with at the Genetics and Genomics Institute and the Center for Biostatistics at the Icahn School of Medicine… $73,199
Benaroya Research Institute At Virginia Mason Dr. Altman and his senior bioinformatician, Naresh Doni Jayavelu, will lead the HIPC “Signatures” IOF project. Specifically, they will coordinate among all HIPC… $75,134
The Trustees Of Columbia University In The City Of New York As part of the HIPC-II Signatures Project, we created the “HIPC Signatures Dashboard”), which enables easy navigation of immune signatures and use by a range of… $71,174
Emory University Dr. Rouphael is a Professor of Medicine at Emory University in the Division of Infectious Diseases. She is the current Stanford/Emory Clinical Core PI, the… $39,125
The General Hospital Corporation This award is a supplement to our already-existing U19. This supplementary award is the administrative core for the overall consortium. Dr. Edlow’s… $75,060
Yale Univ While best known as the most common cause of lower respiratory tract infection in young children, respiratory syncytial virus (RSV) causes substantial morbidity… $140,500
Yale Univ Dr. Steven Kleinstein will oversee the work being carried out at Yale as part of this project. This work will include: • Organization of three… $616,621
Icahn School Of Medicine At Mount Sinai In this project, Dr. Beaumont will oversee the spatial transcriptomics assay and generation of spatial transcriptomics data using the 10X Xenium platform, and… $69,077
The Trustees Of Columbia University In The City Of New York Emerging commercial technologies are enabling single-cell genomic profiling without tissue disruption. For example, the 10x Genomics Xenium platform allows… $55,226
The Children's Hospital Corporation The Immunophenotyping of a Coronavirus Cohort (IMPACC) study has generated unprecedented amounts of multi-omic systems biology data to define biomarkers of… $401,924
Massachusetts Institute Of Technology The Lauffenburger laboratory will oversee computational analysis of the spatial transcriptomics data generated in the Edlow laboratory. The Postdoc will carry… $21,937
Icahn School Of Medicine At Mount Sinai Dr. Kristin Beaumont will perform the Xenium custom panel design and procure both purchased tissue and patient tissue (from MSSM’s Biorepository as… $164,244
Childrens Hospital Medical Center Objectives: The goals of this contract will be to assist in achieving the aims of the HIPC-III Signatures IOF, which will include 1) Expansion of the Immune… $177,898
Seattle Children's Hospital The HIPC Immune Signatures Data Resource will be expanded with new vaccine and infection studies as well as new data from single cell RNA-seq. We will… $88,605
The Trustees Of Columbia University In The City Of New York As part of the HIPC-II Signatures Project, we created the “HIPC Signatures Dashboard�), which enables easy navigation of immune signatures and… $74,025
Massachusetts Institute Of Technology The Lauffenburger laboratory will undertake computational multi-variate data analysis employing machine learning modeling of complex multi-variate relationships… $71,550
Icahn School Of Medicine At Mount Sinai Dr. Mayte Suarez-Farinas is Associate Professor with at the Genetics and Genomics Institute and the Center for Biostatistics at the Icahn School of Medicine… $76,050
Benaroya Research Institute At Virginia Mason Dr. Altman and his senior bioinformatician, Naresh Doni Jayavelu, will lead the HIPC “Signatures� IOF project. Specifically, they will coordinate… $77,985
Yale Univ Identification, standardization, and dissemination of HIPC immune signatures. The ongoing identification of immune “signatures� that associate with… $75,375
Centre Hospitalier Universitaire Vaudois (Chuv) Dr. Gottardo will work closely with the Principal Investigator of the overall project, Bjoern Peters (LJI) to oversee all work to be performed in the Gottardo… $19,844
Show all 46

Quick answers

Who received award U01AI167892?

U01AI167892 was awarded to La Jolla Institute For Immunology by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on April 13, 2022.

How much is award U01AI167892 worth?

$74,668,111 has been obligated on U01AI167892.

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