Proteomic biomarkers of incident cognitive impairment in black and white adults

Active Cooperative Agreement Awarded Last action

Award ID
U01AG082042
Recipient
Awarding agency
Obligated
$4,598,603

Award facts

Assistance listing
93.866 Aging Research
Completion date 51% complete
Place of performance
Chapel Hill, NC 27599, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Black adults in the U.S. Have a disproportionately higher risk of alzheimer's disease and related dementias (adrd) compared with non-hispanic white adults. Disparities in cardiometabolic risk factors and diseases and social determinants of health (such as educational access, stress due to discrimination, neighborhood factors, and others) likely contribute to this disparity, but exact mechanisms are unknown. We hypothesize that inflammation may be a key feature linking cardiometabolic and social determinants of health disparities with the risk of incident cognitive impairment and dementia. We propose to test this hypothesis through systemic analysis of the circulating proteome with risk of incident cognitive impairment and trajectories of cognitive function in a large biracial population from the reasons for geographic and racial differences in stroke (regards) study. Regards is a longitudinal cohort of 30,239 non-hispanic black and white adults across the contiguous U.S. With pre-existing genome-wide genotyping data and rich cardiovascular and neurocognitive phenotyping. We will assess 3,072 circulating plasma proteins (including >700 inflammation related proteins) for associations with risk factors for cognitive impairment, including age, social determinants of health, and cardiometabolic risk factors, and with incident cognitive impairment and trajectories of cognitive function over >17 years of follow-up. Differences in levels of identified proteomic biomarkers by race and SEX will be assessed. Finally, we will integrate available genome-wide genotyping data and the plasma protein data newly generated in this study to determine if the protein data can elucidate mechanisms underlying associations of previously identified genetic variants with dementia-related phenotypes. We hypothesize this work will identify non-invasive protein biomarkers of cognitive impairment and adrd, including risk biomarkers which may have adverse levels in black compared with white adults. This study is responsive to PAR-22-093 (not-AG-21-033: health disparities and alzheimer's disease), assessing biological pathways that may contribute to racial disparities in adrd risk and related to NIA ad+adrd research implementation milestone 1.i. The proteomic data generated in this study will be made widely available to the scientific community through appropriate public repositories (such as dbgap). Results from this study may improve adrd risk prediction, elucidate biological mechanisms of adrd, and improve understanding of factors that contribute to adrd health disparities.

Transactions

Action Obligated Date
Amendment $728,275
Amendment $0
Amendment $0
Amendment $59,373
Amendment $59,373
Amendment $667,946
Amendment $667,946
Amendment $805,230
Amendment $805,230
Original award $805,230

Subawards

Subrecipient Amount Awarded
University Of Washington The University of Washington (UW) investigator will provide expertise in inflammation and thrombosis protein biomarkers and CVD disease-related phenotypes, as… $35,141
Wake Forest University Health Sciences In a collaborative effort, the Wake Forest University Health Sciences investigator will work on the development of study hypothesis, interpretation of cognitive… $48,778
Duke University The overall goal for this project is to identify novel biomarkers which may explain health disparities in Alzheimer's disease and related dementias (ADRD) by… $82,083
Beth Israel Deaconess Medical Center, Inc. In a collaborative effort Beth Israel Deaconess Medical Center (Beth Israel) will perform a targeted proteomics analysis of de-identified human plasma… $1,120,323
University Of Vermont & State Agricultural College The University of Vermont will perform the following work for this project: 1.Oversee and coordinate the sample selection and retrieval; 2. Pull, prepare, and… $264,722
University Of Alabama At Birmingham The University of Alabama will be responsible for conducting proteomic analysis with REGARDS data and ensuring all data needed for the project are available… $167,539

Quick answers

Who received award U01AG082042?

U01AG082042 was awarded to University Of North Carolina At Chapel Hill by National Institute on Aging (National Institutes of Health) on June 1, 2024.

How much is award U01AG082042 worth?

$4,598,603 has been obligated on U01AG082042.

On GovTribe

See this award's full record

  • Every transaction and subaward
  • The recipient's other awards and teaming partners
  • Similar grant awards
  • Ask GovTribe AI about this award
Try for free Login