Project Grant R44DE028718

This $100,000 Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program will support the development of an advanced wound care technology at Florida International University. Specifically, the university will create a bandage-integrated platform that provides feedback-mediated wound therapy to enable personalized care. The conformable platform is designed to non-invasively monitor multiple wound biomarkers in spatial detail and then apply targeted...

This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) provides $649,984 to Gelsana Therapeutics Inc., a woman-owned small business and HUBZone certified corporation, to develop Provasliex Gel, a zwitterionic hydrogel that delivers controlled release of platelet-derived growth factor (PDGF) to promote vascularization and manage inflammation in the...

The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $172,700 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to the University of California, Irvine. The project aims to develop a novel therapeutic approach for improving angiogenesis and wound healing by delivering apoptotic neutrophils within a degradable hydrogel scaffold. The research will investigate the effects of the hydrogel-neutrophil delivery on macrophage...

This Project Grant award, funded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the CFDA program "Discovery and Applied Research for Technological Innovations to Improve Human Health" (93.286), supports the development and validation of an innovative adhesive acrylic surgical drape for use in negative pressure wound therapy (NPWT) applications. The key products or services to be delivered under this $2,433,408 award include: Comparing the performance...

This Project Grant award, with ID R43AG090115, was provided by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866). The $367,577 award, with a performance period from September 15, 2024 to August 31, 2025, is funding Adepthera LLC, a for-profit limited liability company, to develop a regenerative peptide therapy to accelerate pressure ulcer healing. The project aims to identify an optimal formulation of a self-assembling adrenomedullin (ADM)...

The University of Miami School of Medicine is conducting a R21 research project titled "Developing Biomarkers of Healing and Non-Healing VLUs" under a $371,470 award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). The project aims to identify protein biomarkers in wound fluid that can predict healing outcomes and monitor progression of venous leg ulcers (VLUs), a common chronic wound condition. The researchers will analyze discarded wound...

This Cooperative Agreement from the National Institutes of Health (NIH) under the 21st Century Cures Act: Regenerative Medicine Initiative (CFDA 93.370) provides $538,200.00 to The Regents of the University of Colorado, doing business as the University of Colorado-Denver, to conduct a Phase 1 pilot study on the safety and efficacy of induced pluripotent stem cell (iPSC)-based therapy for recessive dystrophic epidermolysis bullosa (RDEB). The study will evaluate the use of genetically...

The National Institute on Aging (NIA) awarded a $295,923 Project Grant (CFDA 93.866 - Aging Research) to Larix Bioscience LLC to develop novel hormonal therapeutics and study their efficacy with adult stem cells for the treatment of chronic pressure ulcers. The project aims to generate stable, bioactive hormone fusion biologics and evaluate their ability to enhance tissue regeneration in pressure ulcer patients, both alone and in combination with adipose-derived or induced pluripotent stem...

This $250,000 National Science Foundation project grant supports the development of a microneedle-mediated adaptive phototherapy wound dressing by the University of South Florida from October 1, 2022 to November 30, 2024. The dressing integrates self-diagnosis and treatment tailored to wound conditions without external electronics or medical professionals. Microstructured microneedles act as optical waveguides to deliver localized blue or red light therapy at wound sites, changing wavelength...

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $305,000 will fund the development of an advanced wound care product to treat diabetic foot ulcers. The product is a microneedle bandage that delivers three therapeutic agents to disinfect the wound, prevent biofilm formation, and activate the immune system to speed healing. Initial work will be performed using skin tissue cultures and testing on diabetic pigs. The project aims to...