Project Grant R43DE028220

This Project Grant award of $466,500.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop near-infrared chemiluminescent and fluorescent (NIR CFL) chitosan-based nanoparticles (CNPs) to improve the detection of micrometastatic cancer and guide image-guided surgery. The nanoparticles can be activated by body heat and stored at low temperatures for convenience and safety. The research...

Federal Grant Award Summary Greenmark Biomedical Inc. received a $270,594 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded September 1, 2025, with a completion date of August 31, 2026. The grant funds development and translation of nano-fluorapatite (NFA) particles designed to restore non-cavitated carious lesions in tooth enamel. Unlike conventional remineralization treatments that...

This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $294,505 to support the development and commercialization of a targeted fluorescence dye for intraoperative imaging and precision surgical treatment of head and neck cancer (HNC). The goal is to create a small peptide-based fluorescent probe that can specifically stain HNC tumors to assist surgeons in identifying tumors...

This National Science Foundation Project Grant of $255,757 awarded on August 15, 2022 will fund the development of an ultrasound-based point-of-care periodontal imaging device under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084). Stylosonic LLC will develop an integrated device for acoustic imaging of the entire mouth that automatically processes imaging data to assist dentists in assessing gingival health and periodontitis. Key objectives include miniaturizing imaging...

This SBIR Phase I Project Grant award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program provides $275,000 to T33 Dental, Inc. to validate a novel device and approach for enhancing the delivery of pharmaceuticals and cosmetics into whole human teeth. The project aims to develop a system to improve the permeability of drugs and cosmetic treatments for addressing tooth decay and enabling more effective dental procedures. Key focus areas...

Federal Grant Award Summary Periomics Care LLC received a $297,711 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded on August 6, 2025, with a completion date of July 31, 2026. This Phase I research initiative focuses on developing zinc nanocrystals derived from zinc tetraammine fluoride (ZAF) as a novel therapeutic agent for caries arrest and remineralization. The project...

The National Science Foundation awarded a $254,360 Project Grant to Quiver Dental, Inc. under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) to develop a diagnostic device to measure dental implant stability. The one-year award running from August 1, 2022 to July 31, 2023 aims to complete proof-of-concept demonstration of a reliable and accurate device using vibrational technology to quantify the degree of motion and stability between a dental implant and surrounding...

The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $421,800 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to Midwestern University. The purpose of this 3-year grant, with a start date of September 7, 2023, is to develop hybrid hydrogel-based dental adhesives that are less vulnerable to hydrolytic degradation compared to current methacrylate-based alternatives. The goal is to create a truly biomimetic dental adhesive that can not only...

This Project Grant from the National Science Foundation supports the development of superparamagnetic, antimicrobial nanocomposites and a magnetic toothbrush for synergistic dental care. Awarded $276,000 on June 1, 2022 under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084), the funding will support MNT Smartsolutions LLC through May 31, 2023. The company will develop a biofunctionalized magnetic nanoparticle ferropaste that can efficiently remove oral bacterial biofilms...

This $349,996 federal Project Grant award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program aims to develop a new dental technology to improve oral health through microbial transplantation. The project will test the use of beneficial oral microbes from healthy donor dental plaque to treat conditions like dental decay and gum disease in recipients. The effort will employ a 3D printed system to grow and propagate the transplanted microbes, with the...