Cooperative Agreement R43DE025526

This Project Grant from the National Science Foundation's Engineering program (CFDA 47.041) provides $249,999 to The Trustees of the University of Pennsylvania for the development of a smart dental implant system. The award will support research and educational activities from September 2022 through August 2025. Specifically, the grantee will build a strategy to prevent peri-implant disease through enhancing soft tissue immunity near dental implants. They will develop an ambulatory care platform...

This SBIR Phase I project, awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program, is focused on the development of a novel mammalian cell-based nano-biological coating for implantable medical devices. The goal is to address the critical health and economic burden associated with implant-related infections by reducing or eliminating them through the use of this biocompatible and antimicrobial nano-biological coating. The $305,000...

The National Science Foundation awarded a $254,360 Project Grant to Quiver Dental, Inc. under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) to develop a diagnostic device to measure dental implant stability. The one-year award running from August 1, 2022 to July 31, 2023 aims to complete proof-of-concept demonstration of a reliable and accurate device using vibrational technology to quantify the degree of motion and stability between a dental implant and surrounding...

This Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program totaling $295,247 will support the development of an innovative medical technology for localized and sustained antibiotic treatment of periprosthetic joint infection. Specifically, the awardee Reselute will design, develop, and validate a proof of concept for an orthopedic spacer implant with a novel porous medium capable of controlled antibiotic elution over 180 days. The implantable...

Federal Grant Award Summary Rytek Medical Inc. received a $296,171 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), effective August 8, 2025, with a completion date of August 7, 2026. The grant supports the development and evaluation of an impedance-based bone assessment technology designed to characterize trabecular bone microarchitecture at dental implant sites. This technology...

Federal Project Grant Award Summary The University of Southern California received a $913,000 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded June 1, 2025, with a completion date of May 31, 2027. This research project aims to develop supramolecular nanomaterial-based approaches for periodontal regeneration by investigating how biomaterials can enhance the biological activity of...

Federal Grant Award Summary The University of Rochester received a $1.69 million Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded May 1, 2025, with a completion date of January 31, 2030. This award funds research into epigenetic therapy approaches for treating peri-implantitis, a clinical condition involving inflammation and bone loss around dental titanium implants. The research...

This SBIR Phase I Project Grant award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program provides $275,000 to T33 Dental, Inc. to validate a novel device and approach for enhancing the delivery of pharmaceuticals and cosmetics into whole human teeth. The project aims to develop a system to improve the permeability of drugs and cosmetic treatments for addressing tooth decay and enabling more effective dental procedures. Key focus areas...

Federal Grant Award Summary Periomics Care LLC received a $297,711 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded on August 6, 2025, with a completion date of July 31, 2026. This Phase I research initiative focuses on developing zinc nanocrystals derived from zinc tetraammine fluoride (ZAF) as a novel therapeutic agent for caries arrest and remineralization. The project...

This $256,000 National Science Foundation Project Grant under the Engineering (47.041) program will support the development of a permanent ceramic antimicrobial coating technology by Nanoionix, LLC. The goal is to synthesize and deposit a pure ceramic coating on relevant substrates that exceeds EPA requirements for generating reactive oxygen species to inactivate viruses and bacteria. Nanoionix will conduct spectroscopic assessments to rapidly evaluate the types and numbers of reactive oxygen...