Cooperative Agreement R43CA211086

This award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) will fund research to develop a smart and connected robotic system for comprehensive diagnosis of abnormal tissues in the abdominal cavity. The $795,932 project, with a period of performance from October 2024 to September 2028, aims to integrate multiple sensing modalities, including flexible endoscopy, ultrasound imaging, and Raman spectroscopy, onto a continuum robot to improve the safety and accuracy of...

This Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program (CFDA 47.084) provides $275,000 to Dcan Biosciences LLC to develop an advanced microfluidic system for cancer diagnosis and monitoring. The system aims to isolate and assess circulating tumor cells (CTCs) and CTC clusters (CTCCs) from patient blood samples to enable highly sensitive and accurate liquid biopsies. Key objectives include designing a hybrid microfluidic device for...

This National Science Foundation (NSF) Engineering grant (CFDA 47.041) awarded to the University of California, San Diego (UCSD) provides $354,066 to develop a smart robotic system for comprehensive cancer diagnosis in the abdominal cavity. The project aims to design a multimodal robotic platform equipped with flexible endoscopy, ultrasound imaging, and Raman spectroscopy capabilities to detect, classify, and stage abnormal tissues. The research involves three key thrusts: 1) integrating...

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Phase I Small Business Innovation Research (SBIR) project grant for $274,990 aims to develop a prototype endoscope diagnostic cancer sensor using laser-activated plasmonic nanobubbles (PNB). The project integrates PNB sensors into a medical device platform and a standard clinical endoscope to perform minimally invasive, optically-based lung cancer diagnostic procedures. The objective is to develop a...

This $400,000 Project Grant awarded by the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) aims to develop a multifunctional electron paramagnetic resonance imaging (EPRI) instrument that can simultaneously acquire maps of tissue oxygen pressure (pO2) and pH. The key objectives are to: 1) develop a 25 mT Halbach-type permanent magnet, 2) create new multi-modal transmit-receive electronics based on field programmable gate array (FPGA) technology, and 3) build...

This Project Grant award from the National Cancer Institute's Cancer Detection and Diagnosis Research program (CFDA 93.394) provides $263,086 to the Sloan-Kettering Institute for Cancer Research to develop a multiparametric endoscopic ultrasound (MPEUS) imaging system for improved pancreatic cancer screening and characterization. The key objectives are to implement real-time MPEUS imaging, which combines B-mode, ultrasensitive microvessel imaging, shear-wave elastography, and quantitative...

The National Cancer Institute (NCI) awarded a 5-year, $637,371 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to Northwestern University. The grant aims to develop a microfluidic platform for the rapid, non-invasive isolation and expansion of circulating tumor-reactive lymphocytes (CTRLs) from the blood of ovarian cancer patients. This innovative technology has the potential to enable a new class of effective, second-line immunotherapies against...

This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering, under the Discovery and Applied Research for Technological Innovations to Improve Human Health (CFDA 93.286) program, supports the development of a high-throughput photoacoustic histology platform for real-time intraoperative pathological diagnosis. The $249,000 award to Case Western Reserve University aims to create an ultrafast reflection-mode UV photoacoustic microscopy system with structured...

The National Institute of Biomedical Imaging and Bioengineering awarded a $1,295,800 Project Grant (Award ID R21EB034798) under the Discovery and Applied Research for Technological Innovations to Improve Human Health (CFDA 93.286) federal grant program to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), for the development of a novel non-rotating nano-optic endoscope capable of 360-degree in vivo imaging. The key objectives of the project are to design...

The National Science Foundation awarded a $275,000 Project Grant to Oraliva, Inc. under the Technology, Innovation, and Partnerships program to develop a portable, programmable single cell cytology platform for the early detection of epithelial cancers. The platform will combine microfluidics and artificial intelligence to classify potentially cancerous tissue in near real-time through multiparameter single-cell analysis and automated evaluation. The objectives are to link different clinical...