Cooperative Agreement R41MH109185

This National Science Foundation Project Grant award of $299,126 will fund research at the University of Chicago from March 1, 2022 through February 29, 2024 to infer neuronal activity from anatomical connectivity maps in simplified neural cell cultures. The goal is to develop methods for understanding how physical wiring relates to activity in neural networks, which can later be applied to whole brain maps. Researchers will record functional activity from a 2D neural cell network, map...

This $124,632 project grant from the National Institute of Neurological Disorders and Stroke will support the development of a testable biologically constrained model for path integration in fruit flies. Funded under the Extramural Research Programs in the Neurosciences and Neurological Disorders program, the awardee will use agent-based modeling, pattern recognition algorithms on flies' search trajectories, and genetic manipulation to test the roles of specific cells in the central complex of...

This $266,538 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports collaborative research on the effects of connectivity architecture and distributed delays in brain network dynamics. The project aims to establish a quantitative framework that considers both spatial connectivity and temporal history of neural interactions, using networks of coupled equations with time delays. The research team, led by The Research...

The National Institutes of Health (NIH) awarded a $1,385,000 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to the Allen Institute, a non-profit research organization, to develop novel techniques for measuring the input-output operations of individual neurons in the mouse cortex. The project aims to overcome challenges in understanding how neurons in the mammalian brain transform their synaptic inputs into outputs, which is critical for designing effective brain-machine...

This National Science Foundation (NSF) Engineering (CFDA 47.041) Project Grant award to Carnegie Mellon University (CMU) provides $500,000 in funding from July 1, 2024 to June 30, 2027 to develop a new computational framework for predicting neuron growth and transport regulation in biological neural circuits (BNCs). The project aims to advance knowledge of the fundamental mechanisms of neural growth, material transport regulation, and circuit dynamics through three specific objectives: (1)...

The University of Texas Health Science Center at Houston was awarded $603,872 under the National Institute of Mental Health's Mental Health Research Grants program to develop tools and methods to map electrical synaptic connectivity in neural networks. The three-year project grant aims to image gap junction connectivity in electron microscopy datasets, estimate the size, strength, and plasticity of gap junctions, and determine coupling conductance through electrophysiological and modeling...

This cooperative agreement from the National Institute of Neurological Disorders and Stroke will fund $8,473,173 for research exploring the neural population codes that support context-dependent behavior. The funding will support a collaborative project between New York University, Riken, and Ecole Normale Superieure from April 15, 2021 through March 31, 2024 under the National Institutes of Health's Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA...

This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $434,610 to the Florida Institute of Technology Inc. (Florida TECH) for the development of light-triggered molecular tools to manipulate neuronal connections and study brain function. The principal investigator, Dr. Nasri Nesnas, will collaborate with neuroscientists, including Dr. Attila Losonczy from Columbia University, to design and utilize these...

Purdue University was awarded a $1,304,216 Project Grant by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) to develop and test a new platform for high-density 3D electrophysiology and two-photon calcium imaging in freely moving animals. The goal is to enable simultaneous recording of millisecond electrical dynamics and spatial mapping of neural circuit activity during natural behaviors to better understand how the brain processes...

This $397,500 Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to study the fundamental principles linking neurodevelopmental processes to the functional organization of neural circuits. The research will utilize a new animal model, Clytia, that is capable of regenerating entire genetically ablated neural subnetworks, to...