Project Grant R41CA235994

Sentire Medical Systems, Inc. was awarded a $256,000 National Science Foundation Project Grant to develop an intraoperative monitoring device to detect bowel injuries during laparoscopic surgical procedures. The goal of the NSF Technology, Innovation, and Partnerships program is to advance science and engineering research leading to breakthrough technologies that address national challenges. Through this award, Sentire Medical will characterize gases present during laparoscopic surgery to...

This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" program (CFDA 93.286), supports the development of a novel surgical instrument called a "Multispectral Kerrison Rongeur" (MKR). The MKR is designed to detect dura and nerve roots during spinal surgery, with the goal of reducing the incidence of iatrogenic damage to these critical...

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) award provides $275,000 to Lensguide Imaging Technology Inc. to develop a miniaturized, 100 μm diameter optical imaging microendoscope for in vivo deep tissue imaging up to 3 mm depth with subcellular resolution. The product will enable researchers to visualize biological dynamics in live animals beyond the superficial tissue layers, facilitating new discoveries across biomedical fields. This SBIR Phase...

This $567,340 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) aims to develop and validate a wide-field fluorescence lifetime (FLT) imaging system for intraoperative detection of sarcoma tumors. The project, led by the Massachusetts Eye and Ear Infirmary, seeks to create a portable FLT imaging system that can provide real-time...

This $1,295,800 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) supports the development of a novel optical endoscope that does not require mechanical rotation to perform 360-degree imaging. The key objectives are to design and fabricate a metasurface that can modulate the transmitted beam direction without rotation, and to...

This $13,340,331 Cooperative Agreement was awarded by the Department of the Interior's Interior Business Center under the Advanced Research Projects Agency for Health (ARPA-H) program (CFDA 93.384) with a performance period from August 15, 2024 to August 14, 2026. The project, titled "MARGIN DIAGNOSTICS (MARGINDX): INTRAOPERATIVE LABEL-FREE MULTI-SCALE MULTI-MODAL OPTICAL SURGICAL IMAGING, GUIDANCE, AND DECISION-MAKING PLATFORM", aims to develop an end-to-end solution to reduce...

This Project Grant award from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394) provides $295,747 to Doseoptics LLC to develop a new surgical imaging system called Pressure-Enhanced Sensing Surgery (PRESS). The PRESS system utilizes a clinically approved contrast agent to enable real-time visualization of tissue oxygenation levels during surgical procedures, with the goal of enhancing the precision and efficacy of oncologic surgeries. The...

This Cooperative Agreement award from the Department of the Interior's Interior Business Center, under the Advanced Research Projects Agency for Health (ARPA-H) program (CFDA 93.384), provides $8,945,662.00 to Emory University to develop an intraoperative end-to-end solution called "MARGINCALL." This system aims to enable non-destructive digital capture of histopathology with minimal processing, combined with a dedicated AI image analysis system. The goal is to reduce the current 25%...

The National Science Foundation awarded Pensievision, Inc. $255,947 under the Technology, Innovation, and Partnerships program (CFDA 47.084) to develop an endoscopic 3D imaging system for evaluating cancers and disorders of the esophagus and pharynx. The Small Business Innovation Research Phase I project will combine liquid lens technology, artificial intelligence software, and astronomical imaging techniques to generate three-dimensional images of early-stage esophageal and throat tumors....

The National Cancer Institute (NCI) awarded a $374,880 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to the University of Alabama at Birmingham (UAB) to conduct a clinical study on a novel combination of intraoperative optical imaging approaches to detect occult tumor margins in patients with laryngeal cancer. The key objectives of the project are to: 1) Establish metrics of intraoperative optical imaging that define pathology-confirmed occult laryngeal...