Cooperative Agreement NA19NOS4820132

This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) Federal Grant Program provides $900,804 to Lena Biosciences, Inc., a woman-owned small business, to develop an integrated microphysiological screening platform with "virtual human" models for assessing chemical toxicity. The key products and services to be delivered include: A 96-well microphysiological screening platform that combines elements of...

This three-year, $3.13 million project grant from the National Institutes of Health's National Institute of Environmental Health Sciences will fund research at Michigan State University investigating the progression of non-alcoholic fatty liver disease. Specifically, the grant will test the hypothesis that activation of the aryl hydrocarbon receptor by environmental contaminants reprograms fatty acid metabolism, causing the accumulation of toxic lipid intermediates that contribute to...

The National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded a $199,999 RAPID Project Grant to the University of Tennessee, Knoxville to monitor the microbial attenuation of toxins released following the East Palestine, Ohio train derailment in February 2023. The project aims to test the hypothesis that microbial communities in contaminated areas will show measurable responses that could inform contaminant degradation and natural...

The Agency for Toxic Substances and Disease Registry (ATSDR) awarded a $999,998.00 Project Grant under the State Capacity Building Federal Grant Program (CFDA 93.240) to the Dartmouth-Hitchcock Clinic on Sep 30, 2024. The grant's objective is to investigate persistent environmental toxicant exposures in the central nervous system tissue of military veterans as potential etiological factors contributing to the development of amyotrophic lateral sclerosis (ALS). Under this grant, the...

This Project Grant award from the National Center for Advancing Translational Sciences (NCATS) under CFDA 93.350 will provide $463,150 to The Regents of the University of California, San Francisco (UCSF) to establish proof-of-concept for enzyme replacement therapy (ERT) as a lifesaving treatment for sphingosine phosphate lyase insufficiency syndrome (SPLIS), an ultra-rare and often lethal metabolic disorder. The project aims to demonstrate the efficacy of ERT in preserving kidney function and...

The National Institute of Environmental Health Sciences (NIEHS) awarded a $238,500 Project Grant under the Environmental Health (CFDA 93.113) federal grant program to the Massachusetts Institute of Technology (MIT) for the project "Leveraging Mutational Analysis of Cell-Free DNA to Identify Carcinogenic Exposure and Enable Early Detection of Cancer". The goal is to develop a novel blood-based analytical tool to rapidly detect mutational profiles of environmental toxicants like...

This Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $299,993 to CMTX Biotech Inc. to develop a novel, host-directed therapeutic for the treatment of sulfur mustard-induced lung injury. The specific objectives are to: Demonstrate a dose-dependent survival benefit of CMTX Biotech's lead drug candidate, Incyclinide, in a rat model of sulfur mustard inhalation exposure, with daily treatment...

This $760,374 federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports a study by National Jewish Health to investigate molecular signatures related to the diagnosis and progression of pulmonary sarcoidosis. The 5-year project aims to use an integrative multi-omics approach, incorporating genetic, gene expression, and metabolomic/lipidomic data, to identify blood-based biomarkers that can...

The National Institute of Environmental Health Sciences (NIEHS) awarded Nexilico, Inc. a $275,765 Project Grant (CFDA 93.113 - Environmental Health) to develop a predictive computational-experimental platform to characterize microbial biotransformation of xenobiotic compounds and identify naturally occurring gut microbial strains that can mitigate xenobiotic toxicity as novel probiotics. The project aims to provide cost-effective yet accurate predictions to identify microbial species capable...

This $500,000 Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program aims to develop a novel human stem cell-based microfluidic developmental toxicology platform. The University of Michigan will receive funding from September 2022 to August 2024 to conduct technological development of a repeatable, controllable, high-throughput microfluidic system for generating three-dimensional multicellular organoid models for toxicity testing. The platform seeks...