Cooperative Agreement HT94252320009

This federal Project Grant award, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), will fund a research project focused on understanding the microbial ecosystem around dental implants and preventing the development of peri-implantitis, a disease that leads to implant failure. The $675,684 award, effective August 1, 2024 through July 31, 2025, will support the Regents of the University of...

This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop a multifunctional, 3D-printed dental implant capable of preventing peri-implantitis, a common and challenging implant-related oral infection. The $1,963,287 award to Cleveland State University will fund the development of silver-doped amorphous magnesium phosphate bioceramic particles, which will be incorporated...

This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under its Oral Diseases and Disorders Research program (CFDA 93.121) provides $434,746 to Nova Southeastern University, Inc. to investigate the impact of diabetes-induced hyperglycemia on the development of peri-implantitis, a common complication following dental implant placement. The project aims to elucidate the mechanisms by which hyperglycemia leads to changes in the oral microbiome and promotes...

This Project Grant from the National Science Foundation's Engineering program (CFDA 47.041) provides $249,999 to The Trustees of the University of Pennsylvania for the development of a smart dental implant system. The award will support research and educational activities from September 2022 through August 2025. Specifically, the grantee will build a strategy to prevent peri-implant disease through enhancing soft tissue immunity near dental implants. They will develop an ambulatory care platform...

This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $304,019 to Panorama Research Incorporated to identify and evaluate a panel of human anti-human OC-STAMP monoclonal antibodies. The goal is to develop a novel therapeutic to slow or halt the loss of alveolar bone and teeth in severe periodontitis. The research will utilize a ligature-induced periodontitis model in a human...

This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will provide $429,000.00 to the Regents of the University of Michigan to conduct research on the unique characteristics of jawbone biology. The research aims to gain a molecular-level understanding of how osteoblasts in the jawbone respond differently to bone morphogenetic protein (BMP) signaling and mechanical loading...

This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will provide $656,315 to Temple University to study the impact of cyclic strain on the pathogenesis of oral microbes, particularly Candida albicans and denture-related microbiota. The goal is to mechanistically understand how biomaterial cyclic strain, driven by chewing forces, can influence the virulence and dysbiosis of oral...

This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $513,574 to the Regents of the University of Michigan to study the mechanisms that lead to osteonecrosis of the jaw (ONJ) in patients taking anti-resorptive medications. The researchers aim to elucidate the cellular and genetic factors that contribute to ONJ, and develop a polygenic risk score to predict susceptibility to...

This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), part of the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $412,610.00 to the Oklahoma Medical Research Foundation (OMRF) to investigate associations between the peripheral blood microbiome and knee osteoarthritis. The key objectives are to determine if baseline peripheral blood bacterial DNA patterns can predict future radiographic and...

This Project Grant award of $498,238 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support a longitudinal study investigating the oral microbiome in children undergoing hematopoietic cell transplants (HCT) at Nationwide Children's Hospital. The key objectives are to: 1) Define changes in the oral microbial community at the species level and relate these changes to the development and progression...