Cooperative Agreement DEEE0006110

This SBIR Phase I award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $275,000 to Caravel Bio, Inc. to develop a novel synthetic biology platform for high-throughput directed evolution of spore-displayed enzymes. The project aims to create customizable enzyme solutions for industrial biocatalyst applications by improving key properties like enzyme activity, stability, and loading density. The technology uses a...

This National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems (CBET) Project Grant of $579,734 awarded to Rutgers, The State University, aims to accelerate the design and development of synthetic enzymes through a combination of artificial intelligence, polymer science, and robotics. The project will implement an iterative design-build-test-learn process to reveal the underlying structure-function relationships that can produce enzyme mimetic...

The National Science Foundation (NSF) has awarded a $2,233,515 Cooperative Agreement to Arzeda Corp under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program. The project aims to transform the production of acrylates, which are high-value chemical components used in products like paints and plastics, by leveraging artificial intelligence (AI)-driven biotechnology. The team will engineer enzymes to utilize non-natural cofactors, enabling a scalable, cost-effective, and...

This Project Grant award from the National Science Foundation (NSF) under the Biological Sciences program (CFDA 47.074) provides $369,297 to San Francisco State University (SFSU) to develop a synthetic transhydrogenation module to enhance the production of valuable chemicals using engineered organisms. The key objectives are to: Elucidate the structural mechanisms underlying the autoregulation of the GltAB-GudB enzyme complex in Bacillus subtilis, which regulates glutamate metabolism and impacts...

This two-year, $200,000 Project Grant from the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems will fund research at the Long Beach Research Foundation to develop multi-activity proteins for improved carbohydrate deconstruction. Specifically, the Foundation will produce and test 85 engineered multi-activity proteins containing two catalytic domains each. These proteins aim to increase biomass conversion for alternative fuels and...

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $274,918 to Cascade Biocatalysts Inc. will fund research and development to demonstrate the commercial feasibility and scalability of a patent-pending approach for stabilizing enzymes through engineered polymer-enzyme interactions. The goal is to enable environmentally sustainable, low-carbon chemical manufacturing processes that utilize enzymes as catalysts, which can decrease...

This Project Grant award from the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program (CFDA 47.070) provides $400,000 to the Massachusetts Institute of Technology (MIT) to develop the ENZYME research ecosystem. The goal is to enable the automatic generation of derivatives for arbitrary programs written in LLVM-based languages, making it easier for scientists and engineers to apply modern algorithms like machine learning to their domains without...

This Project Grant award for $1,000,000 from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) aims to develop a polyketide-based platform to produce a range of non-canonical amino acids (NCAAs) and demonstrate their incorporation into proteins expressed by the bacterium Bacillus subtilis. The key objectives of the 3-year project are to: 1) engineer a polyketide synthase (PKS) system to produce threonine and evolve it for increased productivity; 2) utilize...

This Cooperative Agreement award of $2,572,498.00 from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program, with a performance period from May 1, 2025 to Apr 30, 2028, aims to develop new bioplastics with diverse properties. The project will computationally design complex enzymes within engineered bacteria to produce novel, sturdy bioplastics that can withstand high temperatures and be easily recycled or biodegraded. This effort will strengthen supply...

This SBIR Phase I project, awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084), aims to develop a novel platform for accelerating the strain development process for precision fermentation. The $275,000 grant, awarded on January 15, 2025, will fund the recipient, Terraferma Foods, Inc., to leverage machine learning and experimental biology to enhance the industrial-scale production of animal proteins in yeast. The project...