Develop physics-informed, artificial, AI-driven agents (i.e., decision making software tools) that guide the design of biotherapeutic drug formulations by optimizing measurement campaigns
Active Cooperative Agreement Awarded Last action
- Award ID
- 70NANB25H090
- Recipient
-
Theiss Research UEI F67SDLWMJH17
- Awarding agency
-
National Institute of Standards and Technology
Department of Commerce
- Obligated
- $267,153
Award facts
- Assistance listing
- 11.609 Measurement and Engineering Research and Standards
- Completion date 62% complete
- Place of performance
- La Jolla, CA 92037, USA
Award details come from USAspending.gov.
Description
- Purpose
- The purpose of this grant is to develop physics-informed, artificial, AI-driven agents (i.e., decision making software tools) that guide the design of biotherapeutic drug formulations by optimizing measurement campaigns.
- Activities
- The researcher will develop software tools that use AI and machine learning (ML) techniques to optimally select which compositions and temperatures at which to characterize biotherapeutic formulations. These tools will be integrated into the existing NIST autonomous formulation lab (AFL) software platform and distributed in open-source repositories. Additionally, the researcher will carry out molecular simulation and theory calculations that will be used to improve the A.I. Guidance. Finally, the researcher will benchmark the AI agent's performance by carrying out measurement campaigns using a variety of metrologies (e.g., saxs, sans, UV-VIS, rheology) on real biotherapeutic drug formulations. These measurements will be performed on existing AFL hardware platforms.
- Expected outcomes
- The agent will improve the efficiency of designing biotherapeutic formulations, allowing manufacturers to explore larger and more complex formulation spaces at reduced cost. For the consumer, the agent will enable a greater variety of drug formulations which are cheaper and have minimized cold-chain burden.
- Intended beneficiaries
- The agent developed will support academic, nonprofit, and industry researchers working on the design and manufacture of vaccine formulations, therapeutic protein delivery systems, and reformulation strategies.
- Subrecipient activities
- The recipient does not intend to subaward funds.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $122,464 | |
| Original award | $144,689 |
Quick answers
Who received award 70NANB25H090?
70NANB25H090 was awarded to Theiss Research by National Institute of Standards and Technology (Department of Commerce) on August 1, 2025.
How much is award 70NANB25H090 worth?
$267,153 has been obligated on 70NANB25H090.
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