Develop and test the limits of several schemes for determining single-molecule orientation
Active Cooperative Agreement Awarded Last action
- Award ID
- 70NANB24H230
- Recipient
-
Theiss Research UEI F67SDLWMJH17
- Awarding agency
-
National Institute of Standards and Technology
Department of Commerce
- Obligated
- $282,850
Award facts
- Assistance listing
- 11.609 Measurement and Engineering Research and Standards
- Completion date 69% complete
- Place of performance
- La Jolla, CA 92037, USA
Award details come from USAspending.gov.
Description
- Purpose
- The purpose of this project is to develop and test the limits of several schemes for determining single-molecule orientation.
- Activities
- The researcher will construct a metrological optical microscope test stand and will implement existing and novel methods for determining the orientation of single molecules. He will determine both the theoretical and experimental statistical limits of orientation precision and accuracy for the various methods, and use the knowledge gained to identify the optimal approach for different classes of materials and systems.
- Expected outcomes
- The researcher is developing experimental methods, including calibration artefacts and analytical tools, to generate and extract information from both image data and polarimetric data, and the combination of the two, from single fluorescent molecules. He will use the calibration artefacts and analytical tools to 1] determine the precision and accuracy of molecular orientation measurement for image-based, polarimetry-based, and hybrid methods; 2] identify which methods are best suited for which applications; 3] document and disseminate best practices to the communities of single-molecule optical microscopists.
- Intended beneficiaries
- The microscope designs, analytical tools, calibration artefacts, and best practices produced by this research can be used by other researchers working on the application of single-molecule orientation measurements to polymers, organic optoelectronic materials, and biomolecular systems.
- Subrecipient activities
- The recipient does not plan on any subawards.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $145,000 | |
| Original award | $137,850 |
Quick answers
Who received award 70NANB24H230?
70NANB24H230 was awarded to Theiss Research by National Institute of Standards and Technology (Department of Commerce) on October 1, 2024.
How much is award 70NANB24H230 worth?
$282,850 has been obligated on 70NANB24H230.
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