Use capacitance measurements to understand the energetics of DNA nanostructure to evaluate their use as biosensors
Ended Cooperative Agreement Awarded Last action
- Award ID
- 70NANB24H108
- Recipient
-
Theiss Research UEI F67SDLWMJH17
- Awarding agency
-
National Institute of Standards and Technology
Department of Commerce
- Obligated
- $310,000
Award facts
- Assistance listing
- 11.609 Measurement and Engineering Research and Standards
- Completion date
- Place of performance
- La Jolla, CA 92037, USA
Award details come from USAspending.gov.
Description
- Purpose
- The purpose of this project is to use capacitance measurements to understand the energetics of DNA nanostructure to evaluate their use as biosensors.
- Activities
- The researchers will build new measurement frameworks that will iteratively allow 1) the design a new DNA origami structures, 2) the measurement of their dynamic conformational changes with forster resonant energy transfer (fret) techniques, and 3) correlated surface roughness of the substrate with signal using capacitance measurements of the structure the structures are biased by a DC voltage.
- Expected outcomes
- The researchers are developing a new non-invasive and label free technique to utilize electrical measurements to describe the structure-function relationships in DNA nanostructures. The unique properties of these structures allows these analytical techniques to be useful in specific scenarios in BIO sensing: (1) to reliably design and synthesize nanosensors with pre-determined gain, kinetics and other physio-chemical properties; (2) to better understand the energetics and physics of structure motion under several conditions; and (3) allow the underlying measurements and technology to be utilized in field-deployable tests and products.
- Intended beneficiaries
- The methods generated from this research will be used by researchers working with DNA nanotechnology and when incorporated in sensors will generate big data sets that will be useful in developing machine learning and AI models. The resulting measurements and techniques will lead to improved accuracy in biosensing applications.
- Subrecipient activities
- The recipient does not intend to subaward funds.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $100,000 | |
| Amendment | $65,000 | |
| Amendment | $65,000 | |
| Original award | $80,000 |
Quick answers
Who received award 70NANB24H108?
70NANB24H108 was awarded to Theiss Research by National Institute of Standards and Technology (Department of Commerce) on August 1, 2024.
How much is award 70NANB24H108 worth?
$310,000 has been obligated on 70NANB24H108.
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