Cooperative Agreement 2545371
- This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $275,000 to Cerflux Inc. aims to develop a personalized cancer treatment screening platform. The project will establish guidelines for handling solid tumor biopsy samples, generate 3D bioprinted tumor models for validation, and demonstrate the platform's ability to match patients with the most effective cancer treatments before treatment begins. This innovative approach has the...
- This STTR Phase I Project Grant, awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program, is funding the development of a novel tissue-engineered platform for cancer modeling and drug screening. The $275,000 award to Vivosphere LLC will be used to create a more physiologically relevant and versatile high-throughput screening model that can improve the translation rate between preclinical and clinical testing of anti-cancer...
- The National Science Foundation awarded Opal Therapeutics Inc. a $1.25 million cooperative agreement on August 1, 2026, to develop scalable platforms for translational research and therapeutic screening under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084). The project pursues three primary objectives: expanding a current biobank with increased metadata acquisition; automating culture and imaging workflows using proprietary media formulations to increase throughput and...
- Federal Cooperative Agreement Summary Award: NSF SBIR Phase II: nCapsule Personalized Cancer Screening for Colorectal Cancer Treatment Regimens Funding Agency: National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) Program (CFDA 47.084) Awardee: Encapsulate Inc., Farmington, Connecticut Award Amount: $1,213,619 | Award Date: June 15, 2025 | Completion Date: May 31, 2027 Encapsulate Inc. is developing an integrated precision oncology platform that combines microfluidics,...
- The National Science Foundation awarded Empiri, Inc. a Cooperative Agreement valued at $1,249,794 on July 1, 2026, under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) to develop an automated tumor slice culture instrument that measures cancer patients' drug treatment response. The project refines an automated tissue slicer and handler (ATSH) prototyped in Phase I, with objectives including scaling of sample preparation, refinement and expansion of ATSH design and...
- The National Science Foundation awarded Beken Bio, Inc. a $1,249,464 cooperative agreement on August 1, 2026, under the SBIR Phase II program to develop a liquid biopsy diagnostic tool that detects cancer through extracellular vesicle biomarkers in blood samples. The recipient will conduct a prospective, blinded clinical study of approximately 300 patients undergoing surgery to validate a diagnostic test that measures cancer signals carried by extracellular vesicles (EVs)—tiny particles released...
- The National Science Foundation awarded Rumedical Nova LIMITED Liability Company $305,000 on July 15, 2026, under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) to design and validate a compact chip-based platform for detecting lung cancer biomarkers in blood serum with high sensitivity and speed. The research will focus on developing an innovative nanoscale sensing element capable of recognizing disease signals at extremely low concentrations in a rapid, sensitive, and...
- This $274,990 Small Business Innovation Research (SBIR) Phase I award from the National Science Foundation (CFDA 47.084 - NSF Technology, Innovation, and Partnerships) supports the development of a physics-based machine learning platform for predicting the crystal structure of small drug molecules. The technology aims to accelerate and reduce the cost of early-stage pharmaceutical research and development by computationally analyzing the crystal structure properties that determine key...
- Federal Cooperative Agreement Summary Nexgen Cancer Detection LLC received a $1.25M Cooperative Agreement from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084), awarded June 15, 2025, with completion targeted for May 31, 2027. The award supports a Small Business Innovation Research (SBIR) Phase II project to develop and validate an enriched cancer DNA detection technology for improved cancer diagnostics from blood samples. The...
- This National Science Foundation Project Grant of $255,995 supported Encapsulate Inc. to develop an automated biochip platform for personalized cancer screening under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084). The award period was from May 15, 2022 to April 30, 2023. The platform will grow patient-derived cancer cells outside the body on biochips to screen them against chemotherapy drugs. This addresses the problem that over 70% of cancer patients undergo ineffective...
The National Science Foundation awarded a $1.25 million Cooperative Agreement to Cerflux Inc. on August 1, 2026, under the SBIR Phase II program (CFDA 47.084, NSF Technology, Innovation, and Partnerships). Cerflux will develop a scalable ex vivo testing platform built on three-dimensional tissue engineering to screen anticancer agents against solid tumors. The platform recreates key structural and biological features of tumor tissue outside the body for quantitative drug response testing. Phase II work includes optimizing tissue preparation methods, expanding drug screening across multiple therapies, and integrating artificial intelligence and machine learning-driven image analysis to standardize and scale measurement of treatment effects. The anticipated technical outcome is a standardized, scalable, and certified testing system capable of generating high-resolution, quantitative data. By enabling earlier identification of effective treatment candidates and faster elimination of ineffective ones, the platform is designed to reduce the time and cost of bringing new therapies to market and serve pharmaceutical and biotechnology companies. Performance occurs in Birmingham, Alabama. The period of performance runs from August 1, 2026, through July 31, 2028. The source indicates sub-recipients are planned for this award but does not identify them or describe their work.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.3m | 7/31/26 |