The National Science Foundation Office of Emerging Frontiers and Multidisciplinary Activities awarded a $2 million Project Grant under the Engineering (47.041) federal grant program to The Trustees of the University of Pennsylvania. The four-year award beginning September 2021 will support research into Distributed Ribonucleic Acid (RNA) Manufacturing via Continuous Enzymatic Reaction and Separation in Biphasic Liquid Media. Sub-awards were provided to the University of Oklahoma, University of...
This $750,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports the development of a novel platform to enable rapid and robust identification of functional RNA molecules directly within mammalian cellular environments. The research aims to solve the challenge of RNA structure sensitivity to local environments that has hindered progress in the field of functional RNA discovery. The project will deliver a customized...
This $299,999 National Science Foundation project grant under the Biological Sciences program (CFDA 47.074) will support research exploring the RNA world and RNA-peptide world hypotheses using a novel dynamic combinatorial chemistry system at the University of Houston, a minority-serving institution. The two-year project beginning August 1, 2022 aims to advance understanding of the role of RNA and peptides in the origins of life. Investigators will employ a system using benzonuclease to cleave...
This $100,000 Project Grant awarded by the National Science Foundation (NSF) under the Biological Sciences (CFDA 47.074) program aims to accelerate protein engineering through the integration of cutting-edge artificial intelligence (AI) methods and advanced laboratory automation. The primary objectives are to develop new AI techniques tailored to the unique challenges of protein engineering, and to leverage these AI capabilities to guide the design and discovery of functional proteins with...
This National Science Foundation (NSF) Project Grant, awarded under the Biological Sciences program (CFDA 47.074), provides $750,000 to Stanford University to develop new technologies for studying RNA, the essential molecules that carry genetic information and play crucial roles in cell functions. The key products and services to be delivered under this 3-year award include: Creating non-destructive methods to directly study RNA localization and interactions within living cells, achieving...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $750,000 Project Grant titled "TRANSITIONS: EVOLVING OUR UNDERSTANDING OF DYNAMIC RNA FOLDING AND FUNCTION" to Northwestern University under the Biological Sciences grant program (CFDA 47.074). The objective of this 3-year award is to uncover fundamental principles linking RNA sequence to dynamic RNA folding processes and function in biological systems. The research aims to enhance the...
This $3,000,000 project grant, awarded by the National Science Foundation (NSF) under the Engineering (CFDA 47.041) program, aims to solve the long-standing challenge of developing self-amplifying ribonucleic acid (SARNA) technologies. The project, led by Trustees of Boston University, a private non-profit research university, will: Synthesize a diverse library of modified nucleoside triphosphates (ModNTPs) and use them to produce modified SARNA with extended cellular half-life. Evaluate the...
This $849,713 Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research to elucidate RNA-RNA interaction networks during interbacterial interactions involving the bacterium Pseudomonas aeruginosa. The research team at Boston Children's Hospital seeks to define the small RNA (sRNA) interaction network in P. aeruginosa and decode the regulatory roles played by sRNAs during its interactions with other bacteria. The project will...
This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Project Grant award of $219,117 to the San Diego State University Foundation supports research on the role of RNA structure in the packaging and discovery of RNA bacteriophage genomes. The key objectives are to: Identify the specific RNA structures involved in the selective packaging of RNA bacteriophage genomes, using quantitative packaging experiments and high-throughput sequencing to critically evaluate current...
The National Science Foundation (NSF) awarded a $1,199,997 Project Grant under its Biological Sciences program (CFDA 47.074) to the University of Colorado-Denver. The grant will fund research to improve understanding of the mechanisms underlying messenger RNA (mRNA) localization and translation, and develop machine learning models to better predict protein production from mRNA. The project will apply recent advancements in RNA sequencing technology to study how factors like tRNA abundance and...
The National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) has awarded a $8,500,000 Cooperative Agreement to the University of Pennsylvania and its sub-awardees to establish the Artificial Intelligence-Driven RNA Biofoundry (AIRFOUNDRY). This initiative integrates cutting-edge AI tools, automation, and microfluidics to optimize RNA design, synthesis, and delivery, with the goal of accelerating advancements in RNA research and democratizing access to these technologies. The project involves three multidisciplinary research groups focused on RNA design optimization, delivery vehicle development, and AI-augmented workflows. Complementary technology innovation groups will deliver automated production systems, high-throughput formulation screening, and cross-cutting digital tools. Key sub-awardees include the Children's Hospital of Philadelphia, Drexel University, and the University of Puerto Rico, who will contribute specialized expertise in areas such as high-throughput RNA manufacturing, lipid nanoparticle formulation, and in-line analytics. This collaborative effort aims to revolutionize RNA research and enable a wide range of new applications in healthcare, agriculture, and environmental remediation.