Cooperative Agreement 2304324
- Celldrop Inc. received a $256,000 Small Business Technology Transfer (STTR) Phase I Project Grant award from the National Science Foundation on May 1, 2021 to develop allogeneic stem cell delivery for efficacy-enhanced equine biotherapeutics. The award supports research and development activities at Celldrop's Laramie, Wyoming facility through November 30, 2022. The project aims to advance Celldrop's stem cell delivery platform technology under the NSF's Technology, Innovation, and...
- This $254,580 National Science Foundation Technology, Innovation, and Partnerships project grant funds the development of artificial intelligence-mediated orthopedic implant design and selection software by Med Dimensions, LLC. The Phase I small business innovation research project aims to create a machine learning system that incorporates bone density screening and 2D to 3D reconstruction to generate anatomically-derived implants and guide implant placement for veterinary use. By integrating...
- Nostopharma LLC was awarded a $256,000 Small Business Technology Transfer Phase I Project Grant from the National Science Foundation to develop a sustained-release, biodegradable nanoparticle drug delivery system for treatment of soft tissue trauma complications. Funded under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084), the 12-month project beginning March 1, 2022 aims to demonstrate in vitro and in vivo feasibility of modulating the ectopic bone microenvironment...
- This National Science Foundation Project Grant of $100,000 supports research into polyelectrolyte multilayered surfaces for use in human mesenchymal stem/stromal cell manufacturing. The goal is to develop a scalable and controllable polymeric coating composed of natural polymers to improve the cell expansion process used in producing therapeutic human mesenchymal stromal cells. The coating is constructed via layer-by-layer assembly of collagen and heparin and has been shown to increase cell...
- This SBIR Phase I project, awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program, is focused on the development of a novel mammalian cell-based nano-biological coating for implantable medical devices. The goal is to address the critical health and economic burden associated with implant-related infections by reducing or eliminating them through the use of this biocompatible and antimicrobial nano-biological coating. The $305,000...
- This STTR Phase I Project Grant, awarded by the National Science Foundation (CFDA 47.084 - NSF Technology, Innovation, and Partnerships program), provides $305,000 to Magsorbeo Biomedical Corp to develop a bioabsorbable magnesium alloy for maxillofacial fixation implants. The goal is to create a magnesium-based implant that can temporarily support healing, then gradually be absorbed by the body, eliminating the need for secondary removal surgeries. This innovation aims to improve healthcare...
- The National Science Foundation (NSF) awarded a $273,563 Small Business Innovation Research (SBIR) Phase I grant to Medicarbone Inc. under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program. The objective of this 12-month project is to design, develop, and demonstrate the feasibility of a minimally-invasive intramedullary (IM) sleeve system with an in situ, photocurable, and removable polymeric bone cement for the treatment of orthopedic fractures. The project aims to address...
- This Cooperative Agreement award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program provides $1,250,000 in funding to Biodevek Inc., a Boston-based small business, to advance the development of a novel hydrogel delivery system for managing gastrointestinal (GI) lesions and bleeding. The project aims to create the first sprayable hemostatic hydrogel solution for endoscopic procedures, with the potential to improve outcomes, reduce...
- The National Science Foundation awarded a $750,000 Project Grant to Rutgers, The State University under the Engineering program (CFDA 47.041) from September 1, 2022 to August 31, 2025. The grant funds research to develop an injectable nanoparticle therapy to restore strength and length to damaged tendons and ligaments. Specifically, the university will investigate combining a thermosensitive polymer and crosslinking agent to stabilize joints by quickly strengthening and returning tissues like...
- This Project Grant award from the National Science Foundation's (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program will fund the development of an advanced wound care product to treat diabetic foot ulcers. The $305,000 award to Therapeutic Bandage Products, Inc. will support the creation of a patented microneedle bandage that delivers three therapeutic agents to disinfect the wound, prevent bacterial biofilm formation, and attract white blood cells to aid healing. This...
STTR PHASE II: STEM CELL DELIVERY IN MICROSCOPIC HYDROGEL DROPLETS FOR FASTER AND MORE COMPLETE HEALING OF EQUINE TENDON AND LIGAMENT INJURIES -THE BROADER IMPACT OF THIS SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PHASE II PROJECT INVOLVES CONTINUED DEVELOPMENT OF TECHNOLOGY TO EXTEND THE THERAPEUTIC WINDOW OF CELL-BASED TISSUE REGENERATION THERAPIES. THIS TECHNOLOGY COULD SIGNIFICANTLY ENHANCE THE SCIENTIFIC UNDERSTANDING OF CELLULAR THERAPIES AND ENABLE THE HEALING OF INJURIES MORE RAPIDLY AND LESS INVASIVELY THAN CURRENT TECHNIQUES. A SIGNIFICANT NEED FOR THIS TECHNOLOGY HAS BEEN IDENTIFIED IN THE COMPETITION HORSE MARKET. A SIGNIFICANT FRACTION (98%) OF COMPETITIVE HORSES SUFFERS FROM SOFT TISSUE INJURIES AND MORE THAN 80% OF THESE HORSES DEVELOP A TENDON OR LIGAMENT INJURY. THESE INJURIES CAN TAKE YEARS TO HEAL AND ARE THE LEADING CAUSE OF MISSED PERFORMANCES? DRASTICALLY REDUCING QUALITY OF LIFE FOR THE ANIMAL AND OFTEN NECESSITATING EUTHANASIA. THIS IS A SIGNIFICANT EMOTIONAL AND FINANCIAL PAIN-POINT FOR HORSE OWNERS AND VETERINARIANS. THE TECHNOLOGY BEING DEVELOPED OFFERS A SOLUTION BY PROVIDING VETERINARIANS A MEANS OF HEALING TENDON AND LIGAMENT INJURIES IN A FASTER AND MORE DURABLE MANNER THAN CURRENTLY POSSIBLE, RESULTING IN FEWER MISSED PERFORMANCES, REDUCED NEED FOR ANIMAL EUTHANASIA, AND SIGNIFICANTLY REDUCING EARNING LOSSES. INITIAL IMPLEMENTATION OF THIS TECHNOLOGY IN THE EQUINE MARKET IS EXPECTED TO RESULT IN THE SUBSEQUENT COMMERCIALIZATION OF PRODUCTS TO IMPROVE THE HEALING OF ORTHOPEDIC INJURIES IN HUMANS. THIS PROJECT ADDRESSES THE SLOW HEALING AND FREQUENT REINJURY OF SUPERFICIAL DIGITAL FLEXOR TENDON (SDFT) INJURIES IN ELITE EQUINE ATHLETES. A SIGNIFICANT FRACTION (98%) OF VETERINARIANS USES STEM CELL INJECTIONS TO AID IN RECOVERY OF THESE INJURIES, HOWEVER, THIS STRATEGY HAS LIMITED EFFICACY DUE TO POOR VIABILITY OF INJECTED CELLS AND SHORT CELL RETENTION TIMES AT THE SITE OF INJURY. THIS PROBLEM IS ADDRESSED BY THIS TECHNOLOGY TO PRESERVE AND LOCALIZE MESENCHYMAL STEM CELLS (MSCS) AT AN INJURY SITE THROUGH DELIVERY IN INERT, INJECTABLE HYDROGEL MICROPARTICLES. THE RESEARCH OBJECTIVES ARE TWOFOLD: 1) EXAMINE EARLY HEALING METRICS IN AN EQUINE MODEL OF SDFT INJURY TREATED WITH ENCAPSULATED MSCS COMPARED TO CONVENTIONAL UNENCAPSULATED MSCS, AND 2) EXAMINE LONG TERM HEALING METRICS USING THE SAME MODEL. THE GOAL OF THIS RESEARCH IS TO PROVIDE EVIDENCE OF TWO KEY CUSTOMER NEEDS: FASTER TISSUE HEALING AND MORE DURABLE TISSUE REGENERATION OF SDFT INJURIES. FUNCTIONAL, HISTOLOGICAL, GENETIC, AND BIOMECHANICAL METRICS WILL BE USED TO ASSESS EXPERIMENTAL OUTCOMES AND THE RESULTS ARE ANTICIPATED TO LEAD DIRECTLY TO A CLINICAL TRIAL IN ELITE EQUINE ATHLETES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $500.0k | 9/18/25 | ||
| Not listed | $199.7k | 9/12/25 | ||
| Not listed | $200.0k | 9/4/25 | ||
| Not listed | $0 | 8/13/25 | ||
| Not listed | $0 | 8/13/25 |