Cooperative Agreement 2222933
- This SBIR Phase I project, funded by a $305,000 award from the National Science Foundation's (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program, aims to develop a microchip-based technology for complex, multidimensional cell reprogramming. The project seeks to create a miniaturized liquid and cell handling system that leverages acoustic-electric micro-vortices to precisely and sequentially deliver genetic molecules, making advanced cell engineering more accessible across...
- The National Science Foundation awarded Cytorecovery Inc. a $255,986 Small Business Technology Transfer Phase I Project Grant under the Engineering program (CFDA 47.041) on March 15, 2021. The grant funded the development of on-chip integration of sample preparation and monitoring capabilities with dielectrophoretic cell isolation techniques. The Engineering program seeks to improve quality of life and economic strength by fostering innovation and excellence in engineering research. This award...
- This SBIR Phase I project, awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program, aims to develop an automated system to streamline the sample preparation process for liquid biopsy cancer testing. The $305,000 award will fund the creation of a microfluidic-based instrument that automates the bisulfite conversion step, a critical but time-consuming and error-prone process in preparing circulating tumor DNA for epigenetic...
- This Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program (CFDA 47.084) provides $275,000 to Dcan Biosciences LLC to develop an advanced microfluidic system for cancer diagnosis and monitoring. The system aims to isolate and assess circulating tumor cells (CTCs) and CTC clusters (CTCCs) from patient blood samples to enable highly sensitive and accurate liquid biopsies. Key objectives include designing a hybrid microfluidic device for...
- This $125,805 Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) aims to develop new cell sorting technologies that can identify and separate cells based on changes in the activity of naturally occurring light-emitting molecules like NAD(P)H. The goal is to enable label-free, rapid identification and purification of cell populations, with a focus on stem cells and their functional subsets. The research will create a single cell deposition module to...
- This $256,000 National Science Foundation Project Grant under the NSF Technology, Innovation, and Partnerships program will support the development of a universal connector for high-density microfluidic chip interfaces by Neptune Fluid Flow Systems LLC. The proposed connector aims to advance lab-on-a-chip and other life science platforms by introducing a standardized microfluidic chip interface. This new interface seeks to dramatically increase diagnostic testing speeds for doctors and medical...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program provides $306,860 to Mixedlcmedia LLC, a small disadvantaged business, to develop and evaluate a prototype ultra-low flow liquid chromatography platform based on their proprietary porous layer open-tubular (PLOT) and monolithic nanocolumn technologies. The goal is to create a commercialization-ready LC system that enables deep proteomic...
- The National Science Foundation awarded a $275,000 Project Grant to Oraliva, Inc. under the Technology, Innovation, and Partnerships program to develop a portable, programmable single cell cytology platform for the early detection of epithelial cancers. The platform will combine microfluidics and artificial intelligence to classify potentially cancerous tissue in near real-time through multiparameter single-cell analysis and automated evaluation. The objectives are to link different clinical...
- Micropure Genomics Inc. received a $274,199 Project Grant award from the National Science Foundation to advance methods for rapid, end-to-end sample preparation for sequencing applications. Under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084), the company will develop an automated process relying on electro-hydrodynamic trapping to isolate genomic material like DNA or RNA from cells in a flow cartridge. The process aims to significantly reduce preparation time while...
- This $305,000 STTR Phase I Project Grant awarded by the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program aims to develop an ultra-sensitive biosensor capable of protein analysis at single-molecule resolution. The biosensor consists of a nanopatterned chip with a proprietary scaffold material that binds and immobilizes molecular targets, which are then detected using surface-enhanced Raman spectroscopy (SERS). This innovation seeks...
SBIR PHASE II: BIOELECTRICAL CELL ENRICHMENT, SORTING, AND RECOVERY WITH ON-CHIP SAMPLE PREP AND MONITORING -THE BROADER IMPACT/COMMERCIAL POTENTIAL OF THIS SMALL BUSINESS INNOVATION RESEARCH (SBIR) PHASE II PROJECT IS A LABEL-FREE, BIOLOGICAL SAMPLE PREPARATION AND CELL ISOLATION PLATFORM FOR RECOVERY OF RARE CELLS FROM A VARIETY OF SAMPLE INPUTS. SPECIFICALLY, BY CARRYING OUT SAMPLE PREPARATION, MANIPULATION, AND MONITORING ON A SINGLE CHIP PLATFORM FOR SELECTIVE CELL RECOVERY, THE SAMPLE HANDLING STEPS WILL BE GREATLY REDUCED, THEREBY ENSURING THE MAINTENANCE OF CELL VIABILITY, IMPROVING SAMPLE CONSISTENCY, AND SUSTAINING NATIVE CELL BEHAVIORS. THIS RECOVERED SAMPLE IS ESSENTIAL FOR THE DEVELOPMENT OF CELL-BASED THERAPIES IN REGENERATIVE MEDICINE AND CANCER MANAGEMENT. PERSONALIZED MEDICINE ALSO REQUIRES PRECISION CELL RECOVERIES. THIS SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PHASE I PROJECT WILL DEVELOP AN ELECTRICALLY FUNCTIONAL MICROFLUIDIC SAMPLE MANIPULATION PLATFORM FOR PHENOTYPE-SELECTIVE RECOVERY OF CELLS, BASED ON THEIR BIOPHYSICAL ATTRIBUTES. SPECIFICALLY, MICROFLUIDIC DESIGNS WILL BE INTEGRATED TO SWAP CELLS FROM COMPLEX BIOLOGICAL INPUTS INTO AN OPTIMIZED BUFFER TO ENABLE CELL MANIPULATION. ALSO, INSTRUMENTATION WILL BE DEVELOPED FOR ON-CHIP MONITORING OF THE SAMPLE DURING VARIOUS STAGES OF THE PHENOTYPE-SELECTIVE CELL RECOVERY PROCESS. FURTHER, A VARIETY OF SAMPLE INPUTS WILL BE VALIDATED ON THE DESIGNED DEVICES TO ENSURE PERFORMANCE, CONSISTENCY, AND RELIABILITY FOR TRANSLATION INTO COMMERCIAL PRODUCT LINES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 4/28/25 | ||
| Not listed | $342.2k | 9/11/24 | ||
| Not listed | $952.6k | 2/6/23 |