Block Grant W911QY2410002

This Project Grant awarded by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program provides $295,734 to Litron Laboratories Ltd, a for-profit biotechnology company, to develop a comprehensive hen's egg model for genotoxicity testing. The project aims to create a non-animal, metabolically-active in vitro system that can effectively assess the genotoxic risk of pharmaceuticals and industrial chemicals. Key deliverables include...

This $500,000 Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program aims to develop a novel human stem cell-based microfluidic developmental toxicology platform. The University of Michigan will receive funding from September 2022 to August 2024 to conduct technological development of a repeatable, controllable, high-throughput microfluidic system for generating three-dimensional multicellular organoid models for toxicity testing. The platform seeks...

The National Institute of Environmental Health Sciences (NIEHS) awarded Nexilico, Inc. a $275,765 Project Grant (CFDA 93.113 - Environmental Health) to develop a predictive computational-experimental platform to characterize microbial biotransformation of xenobiotic compounds and identify naturally occurring gut microbial strains that can mitigate xenobiotic toxicity as novel probiotics. The project aims to provide cost-effective yet accurate predictions to identify microbial species capable...

This $900,804 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) federal grant program supports the development and validation of an integrated microphysiological screening platform (MPS) with "virtual human" models to assess chemical toxicity. The key products and services to be delivered include: A 96-well MPS screening platform that combines elements of the awardee's commercial 48-well MPS with highly...

This $617,327 federal Project Grant award, administered by the USDA National Institute of Food and Agriculture (NIFA) under the Agriculture and Food Research Initiative (CFDA 10.310), is for the development of a simple, sensitive, and low-cost technique to detect mycotoxins in food products. The technique utilizes metallic nanoparticles that act as enzyme mimics to generate a colorimetric signal that can be easily detected. This innovative approach aims to address the challenges associated...

The National Institute of Environmental Health Sciences (NIEHS) awarded Xcellassay, Inc. a $306,872 Project Grant under the Environmental Health (CFDA 93.113) federal grant program. The grant funding will support the development and characterization of a hand-held, bioassay-based test strip for rapid, in-field detection of water contamination by endocrine-disrupting chemicals (EDCs). The goal is to create a 1 x 1.5 cm detection strip printed with 20 nuclear receptor sensors that can be...

The National Institute of Environmental Health Sciences (NIEHS) awarded a $260,993 Project Grant (CFDA 93.113 - Environmental Health) to Framergy Inc., in collaboration with Texas A&M University, to develop a novel at-home test kit for the detection of per- and polyfluoroalkyl substances (PFAS) in drinking water. The project leverages the unique properties of metal-organic frameworks (MOFs) and a readily available oxidant to achieve mineralization of PFAS into fluoride ions, which can then...

The Health and Environmental Sciences Institute (HESI) was awarded a $350,000 Cooperative Agreement under the Food and Drug Administration (FDA) Research program (CFDA 93.103) to establish the Nitrosamines Forum for Advancing Critical Translational Science (NA FACTS). The NA FACTS project will form two multi-stakeholder advisory teams to: 1) identify, prioritize, and provide recommendations on in vivo and in vitro research for assessing nitrosamine impurities in drugs, and 2) design and...

The Food and Drug Administration (FDA) awarded a $138,784 Cooperative Agreement under the FDA Research program (CFDA 93.103) to Washington State University (WSU) to validate a standardized high-performance liquid chromatography with fluorescence detection (HPLC-FLD) method for quantifying thiamine (vitamin B1) levels in animal feeds, tissues, and blood. The project aims to develop a testing protocol that can be implemented across the Veterinary Laboratory Investigation and Response Network...

The federal Project Grant award from the National Center for Advancing Translational Sciences (NCATS), part of the 93.350 CFDA program, will support the development of a novel biosensor for the detection of bacterial endotoxins. Through this $290,066 award, the awardee Monod Bio, Inc. will focus on (I) computational design and experimental selection of functional lipopolysaccharide (LPS) bioluminescent biosensors, (II) in vitro evolution of these biosensors to optimize sensitivity and stability,...