Block Grant R01HG003580

Armonica Technologies, Inc. was awarded a $1,047,600 Project Grant from the National Human Genome Research Institute of the Department of Health and Human Services to develop a novel DNA sequencing platform. The award was made under the Human Genome Research program (CFDA 93.172), which supports technologies to accelerate genomic research and its application to human health. Specifically, Armonica will use the funding to optimize a metal-insulator-metal structure for single base sensitivity...

The National Human Genome Research Institute (NHGRI), under the Human Genome Research Federal Grant Program (CFDA 93.172), awarded a $384,418 Project Grant to Xgenomes Corp. on September 25, 2024 to develop a revolutionary DNA sequencing platform. The project aims to create a super-resolution single-molecule sequencing technology that can read short sequence "words" rather than individual nucleotides, enabling one or more orders of magnitude improvements in accuracy and cost over...

This federal Project Grant award from the National Human Genome Research Institute (NHGRI), under the Human Genome Research program (CFDA 93.172), aims to develop SPINSEQ, an innovative RNA sequencing platform that can accurately detect and quantify critical RNA modifications. The $383,482 award, granted on June 6, 2025, will fund the Phase I development and optimization of the SPINSEQ technology, which seeks to overcome the limitations of existing RNA sequencing methods by preserving RNA...

This Project Grant award from the National Human Genome Research Institute (NHGRI), under the Human Genome Research federal grant program (CFDA 93.172), will provide $215,088 to Directseq Biosciences, Inc. to develop an exhaustive de novo RNA sequencing method using next-generation mass spectrometry (NGMS-seq). The objective is to create a technology that can directly identify and sequence every RNA species in a sample, while also comprehensively profiling all RNA modifications, without bias....

Micropure Genomics Inc. received a $274,199 Project Grant award from the National Science Foundation to advance methods for rapid, end-to-end sample preparation for sequencing applications. Under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084), the company will develop an automated process relying on electro-hydrodynamic trapping to isolate genomic material like DNA or RNA from cells in a flow cartridge. The process aims to significantly reduce preparation time while...

This federal Project Grant award of $350,000 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the development of a neural network-accelerated DNA and RNA sequence processing node, called CLEDGESEQ, for use in field, clinical, and industrial settings. The project aims to create advanced sequence analysis and communication capabilities for edge applications, enabling cost-effective and scalable DNA/RNA...

Sequegenics LLC received a $251,073 Project Grant award from the National Science Foundation Division of Industrial Innovation under the Engineering federal grant program (CFDA 47.041). The grant supports development of low-cost and scalable methods for creating genomic databases using long-read next-generation DNA sequencing technologies. This aligns with the program's goals of fostering innovation in engineering research. The one-year project period runs from August 1, 2021 through July 31,...

The federal Project Grant award R01EB037031, provided by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), will develop living biosensors capable of detecting and analyzing DNA from raw samples without requiring sample purification or specialized equipment. The $257,807 award, spanning from April 2025 to March 2029, will focus on demonstrating the...

This Project Grant award from the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program (CFDA 47.070) provides $121,781 to Arizona State University (ASU) to develop new computational methods and hardware architectures for fast and efficient DNA sequence alignment. The goal is to enable rapid large-scale genomic data analytics, which can support various disease studies and biomedical applications. The project will leverage innovations in...

This federal Project Grant award from the National Human Genome Research Institute (NHGRI), under the Human Genome Research CFDA program (93.172), provides $406,500 to Directseq Biosciences, Inc. to advance next-generation mass spectrometry-based sequencing (NGMS-SEQ) methods. The primary objectives are to 1) develop high-throughput NGMS-SEQ techniques for direct sequencing of transfer RNA (tRNA) samples, including physiologically relevant ones, and 2) enhance technologies to quantitatively...