This phase i effort will explore three stabilization strategies--directed mutagenesis, polymer-based nanoparticle encapsulation, and covalent enzyme functionalization--to generate robust PTE-based…

Ended Purchase Order Awarded Last action

Contract number
W911NF25PA012
Awardee
Awarding agency
Obligated
$209,542

Award facts

Contract value 100% obligated
$209,542.11 Current and potential, with all options
Completion date 100% complete
Current and potential, with all options
Funding agency
Research Development and Engineering Command Army Materiel Command, Department of Defense
Set-aside
Total Small Business
Competition
Full and Open Competition after exclusion of sources · 3 offers Negotiated Proposal / Quote
Pricing
Firm Fixed Price
Place of performance
Huntsville, AL 35806, USA
Research
SBIR Program Phase I Action

Award details come from SAM.gov/FPDS.

Transactions

Action Obligated Date
Other Administrative Action P00001 $0
Original award $209,542

About this award

NOU Systems Inc., a certified women-owned small business headquartered in Huntsville, Alabama, has been awarded a Phase I Small Business Innovation Research (SBIR) contract valued at $209,542 by the U.S. Army Research, Development and Engineering Command (RDECOM). The contract, awarded on August 18, 2025, with completion targeted for February 17, 2026, is set aside for small businesses and structured as a firm fixed-price purchase order. The research effort will explore three enzyme stabilization strategies—directed mutagenesis, polymer-based nanoparticle encapsulation, and covalent enzyme functionalization—to develop robust phosphotriesterase (PTE)-based therapeutics suitable for advancement to Phase II development.

This SBIR Phase I award supports the Army's broader research initiatives in advanced biotechnology and enzyme engineering, with work to be performed at NOU Systems' Huntsville location. The contract represents a continuation of the company's established track record in securing SBIR/STTR funding across multiple federal defense agencies. NOU Systems' expertise in scientific research and development, combined with its status as a women-owned small business, aligns with federal priorities for expanding innovation capacity within the small business community while advancing critical defense-relevant biotechnology capabilities.

Description

This phase i effort will explore three stabilization strategies--directed mutagenesis, polymer-based nanoparticle encapsulation, and covalent enzyme functionalization--to generate robust PTE-based therapeutics ready for phase II development.

Quick answers

Who was awarded contract W911NF25PA012?

W911NF25PA012 was awarded to NOU Systems Inc. by ACC Aberdeen Proving Ground (Army Contracting Command) on August 18, 2025.

How much is contract W911NF25PA012 worth?

The government has obligated $209,542 on W911NF25PA012.

Which agency awarded contract W911NF25PA012?

ACC Aberdeen Proving Ground (Army Contracting Command) awarded W911NF25PA012, with funding from Research Development and Engineering Command (Army Materiel Command).

Was contract W911NF25PA012 competed?

The extent of competition for W911NF25PA012 was full and open competition after exclusion of sources. The government received 3 offers. It was set aside: Total Small Business.

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