Purchase Order 75N95022P00202

The National Center for Advancing Translational Sciences (NCATS), a component of the National Institutes of Health (NIH), awarded a $23,940.00 firm-fixed-price purchase order to Life Technologies Corporation, a division of Thermo Fisher Scientific, for a View RNA in situ hybridization (ISH) cell assay kit. This acquisition supports NCATS' Cooperative Research and Development Agreement (CRADA) for Alagille syndrome (ALGS) research, specifically to screen compound libraries for activators of the...

The Department of Health and Human Services National Institutes of Health National Center for Advancing Translational Sciences (NCATS) awarded a $150,000.00 firm fixed-price purchase order to 3Dnamics Inc., a biotechnology company, for services related to the differentiation and characterization of induced pluripotent stem cell (iPSC) lines. This non-competitive commercial item acquisition was conducted under simplified acquisition procedures without a small business set-aside. The services...

This contract was awarded by the Department of Health and Human Services' National Institutes of Health (NIH) National Institute on Drug Abuse to Applied Stemcell, Inc., a minority-owned, woman-owned small business, for a firm-fixed-price purchase order in the amount of $63,000.00. The contract calls for the use of CRISPR gene editing technology to create two custom induced pluripotent stem cell (iPSC) reporter cell lines - one with dual gene knock-ins for albumin and alpha-fetoprotein, and...

Genomic Testing Cooperative, LCA has been awarded a firm fixed price purchase order valued at fifteen thousand dollars by the Department of Health and Human Services' National Institutes of Health National Heart, Lung and Blood Institute. The contract calls for the contractor to provide sequencing of bone marrow samples in order to aid patients' diagnosis and treatment guidance for diseases, as described in solicitation 24-007899. No set aside designation was applied to this award. Performance...

This contract award to Gempharmatech LLC, a foreign-owned biotechnology company in San Diego, California, is for a $58,936 fixed-price purchase order to evaluate the safety of the compound YC1 in mice with humanized SULT1A1 proteins versus standard mouse SULT1A1 proteins. The contract was awarded by the National Center for Advancing Translational Sciences (NCATS), which operates under the National Institutes of Health within the Department of Health and Human Services. The objective is to...

This federal contract award was issued by the National Heart, Lung, and Blood Institute (NHLBI), a component of the National Institutes of Health (NIH), to Social & Scientific Systems, Inc., a subsidiary of DLH Holdings Corp. The $2,800,040 award is for Task Order 5 under the Gene Therapy Resource Program (GTRP) Clinical Coordinating Center, specifically for Task Area B related to clinical trials in fiscal year 2015. The contract is a cost-plus-fixed-fee type and does not have a set-aside...

The U.S. Department of Health and Human Services' National Institutes of Health National Center for Advancing Translational Sciences (NCATS) awarded a $204,715.60 firm-fixed-price purchase order to Charles River Laboratories, Inc. to conduct a non-GLP 50 antisense oligonucleotide (ASO) liver toxicity study in mice. The purpose is to develop a predictive model of candidate ASO therapies' safety and acute toxicity, supporting NCATS' efforts to accelerate the development of effective treatments for...

This firm fixed-price purchase order for $18,204.88 was awarded by the Department of Health and Human Services' National Institutes of Health National Institute on Drug Abuse to Genscript USA Inc. to obtain cell lines utilizing CRISPR gene editing technology. Specifically, the contract calls for Genscript to generate knockout HEK293 and HepG2 cell lines of the MMAB and MUT genes to support studies for hereditary disorders of vitamin B12 and methylmalonic acid metabolism. No set-aside designation...

The Department of Health and Human Services National Institutes of Health National Institute on Drug Abuse awarded a $205,953 firm fixed-price purchase order to the Jackson Laboratory, a non-profit biomedical research institution, to generate a collection of engineered isogenic Alzheimer's diseases and related dementias (ADRD)-mutation induced pluripotent stem cell (iPSC) lines. The work was originally posted as a Sources Sought notice to identify qualified vendors, with no set-aside...

This is a $90,414 firm fixed-price purchase order awarded by the National Center for Advancing Translational Sciences (NCATS), a civilian agency within the Department of Health and Human Services, to Insphero Inc., a foreign-owned, for-profit manufacturer of 3D cell culture technologies and in vitro models. The contract is for a Liver Assay in Liver Spheroids to evaluate the toxicity of short interfering RNA (siRNA) and antisense oligonucleotides (ASOs), which are increasingly being used as...