Brand-Name Biotage Isolera Dalton 2000 or equal normal phase flash chromatography with automated mass spectrometry
(i) This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Subpart 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued. (ii) The solicitation number is 75N95021Q00132 and the solicitation is issued as a request for quotation (RFQ). This acquisition is for a commercial item and is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13—Simplified Acquisition Procedures; and FAR Part 12—Acquisition of Commercial Items, and is not expected to exceed the simplified acquisition teshold. (iii) The solicitation document and incorporated provisions and clauses are those in effect tough Federal Acquisition Circular (FAC) Number 2021-05, with effective date March 10, 2021 (iv) The associated NAICS code 334516 and the small business size standard 1000 employees. This requirement is set-aside for small business. DESCRIPTION (v) National Center for Advancing Translational Sciences (NCATS) chemists confirm the mass of compounds eluting in fractions collected during flash silica gel purification by manually taking aliquots from several fractions, entering these aliquots to separately located reverse phase Liquid Comatography Mass Spectrometry (LCMS) systems, and then waiting for LCMS results to determine what fractions contain compounds of their interest. The normal phase flash comatography with automated mass such as the Biotage Isolera Dalton 2000 (Brand-name) will be a dedicated normal flash purification system that will not only collect fractions based on UV but also acquire the mass spectrum of compounds while they are being eluted into fractions. This will significantly cut down the manual step of acquiring the LCMS separately of fractions in order to verify the identity of the compounds. Moreover, the fractions collected in multiple test tubes in the Isolera test tube racks are compatible with a Biotage V-10 evaporator (with Gilson liquid handler) that already exists in the lab. This will allow the fractions to be consolidated and concentrated into vials using the V-10/Gilson automation: another significant step towards automation. The National Center for Advancing Translational Sciences (NCATS) intents to acquire a normal phase flash comatography with automated mass spectrometry in order minimize manual steps in the chemist’s workflow of fraction collection and mass verification for compound identification during purification by comatography. (vi) Generic Name of Product: Normal Phase Flash Comatography with automated Mass Spectrometry. Purchase Description: For reference purposes, the normal phase flash purifications comatography system with automated mass directed fraction collection that meets the need of this requirement is the Brand-Name Biotage Isolera Dalton 2000 described below (PDF Version Attached): Part Number (PN) QTD Description ISO-1SV 1 Isolera™ One, One Channel, Single Collection Bed, 200-400 nm Detector DALT-2000-APCI-115V 1 Biotage Dalton 2000 Mass Detector APCI 115 VAC incl roughing pump DALT-2000-NLINK 1 Biotage Dalton 2000 Nanolink DALT-2000-SW 1 Spektra License for Dalton 2000 UP-ASAP-SNL 1 Dalton 2000 ASAP kit, probe, capillary stand, APCI source port CAP-ASAP 1 Dalton 2000 Glass capillaries for ASAP IS-ESI-S01 1 Electrospray Ionization (ESI) ion source 415895SP 1 Replacement ESI capillary kit for ALL CMS models (includes capillary, sleeve, and fitting) 415896SP 1 Replacement APCI capillary kit (includes capillary, sleeve, and fitting) for S and L CMS models 413320 1 Solvent bottle caps with silicone and nitril septa, 38-430 414506 1 Stylus Pen Kit for capacitive screens 415867 1 ESI Calibration/tune standard mix SER-ISD2K-FYMP 1 First Year Maintenance Package - Isolera 1 plus Dalton The salient physical, functional, or performance characteristics that “equal” products must meet are as follows: A high-pressure liquid comatography system that can handle purification of organic compounds from reaction mixtures with masses ranging from a few mg to 100 g using silica gel columns of sizes 1g-500g; Automated fraction collection in racks that are compatible in size and functionality with Biotage V-10 evaporator for fraction consolidation; The fraction collections should have the ability to monitor specific UV wavelength and should have an ESI/APCI mass detector to enable collection fractions with a specific mass; Initial installation and familiarization of users on basic operation and maintenance of the system including one Preventive Maintenance visit within 12 months from award; and Shipping and Handling. (vii) The Government anticipates award of a firm fixed-price purchase order for this acquisition, and the anticipated delivery date is within 60 (sixty) days after receipt of order (ARO). The exact date and time of installation and training shall be coordinated with the NCATS Point of Contact listed on the purchase order. Delivery shall be made to the below address with FOB Destination. National Center for Advancing Translational Sciences (NCATS) 9800 Medical Center Drive Rockville, MD 20850 TERMS AND CONDITIONS, PROVISIONS, AND REPRESENTATIONS (viii) The provision at FAR 52.252-1, Solicitation Provisions Incorporated by Reference (Feb 1998), applies to this acquisition. This solicitation incorporates one or more solicitation provisions by reference, with the same force and effect as if they were given in full text. Upon request, the Contracting Officer will make their full text available. The offeror is cautioned that the listed provisions may include blocks that must be completed by the offeror and submitted with its quotation or offer. In lieu of submitting the full text of those provisions, the offeror may identify the provision by paragraph identifier and provide the appropriate information with its quotation or offer. Also, the full text of a solicitation provision may be accessed electronically at these addresses: https://www.acquisition.gov/browse/index/far https://www.hhs.gov/grants/contracts/contract-policies-regulations/hhsar/index.html (End of provision) The following provisions apply to this acquisition and are incorporated by reference: FAR 52.204-7, System for Award Management (Oct 2018) FAR 52.204-16, Commercial and Government Entity Code Reporting (Aug 2020) FAR 52.204-24 Representation Regarding Certain Telecommunications and Video Surveillance Services or Equipment (Oct 2020) FAR 52.204-26 Covered Telecommunications Equipment or Services-Representation (Oct 2020) FAR 52.211-6, Brand Name or Equal (Aug 1999) FAR 52.212-1, Instructions to Offerors-Commercial Items (Jun 2020) FAR 52.212-3, Offeror Representations and Certifications-Commercial Items (Feb 2021) FAR 52.225-2, Buy American Certificate (Feb 2021) HHSAR 352.239-73, Electronic and Information Technology Accessibility Notice (December 18, 2015) The clause at FAR 52.252-2, Clauses Incorporated by Reference (Feb 1998), applies to this acquisition. This contract incorporates one or more clauses by reference, with the same force and effect as if they were given in full text. Upon request, the Contracting Officer will make their full text available. Also, the full text of a clause may be accessed electronically at these addresses: https://www.acquisition.gov/browse/index/far https://www.hhs.gov/grants/contracts/contract-policies-regulations/hhsar/index.html (End of clause) The following clauses apply to this acquisition and are incorporated by reference: FAR 52.204-13, System for Award Management Maintenance (Oct 2018) FAR 52.204-18, Commercial and Government Entity Code Maintenance (Aug 2020) FAR 52.212-4, Contract Terms and Conditions--Commercial Items (Oct 2018). (ix) Offerors are to include a completed copy of the provision at FAR clause 52.212-3, Offeror Representations and Certifications—Commercial Items (Feb 2021), with offers. (x) The clause at FAR 52.212-4, Contract Terms and Conditions-Commercial Items (Oct 2018), applies to this acquisition. Addendum to this FAR clause applies to this acquisition and is attached. FAR 52.212-4 Addendum – Supplier License Agreements, attached. FAR 52.212-4(g), Invoice, is supplemented by: NIH Invoice and Payment Instructions (Feb 2021) (xi) The clause at FAR 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders-Commercial Items (Jan 2021), applies to this acquisition and is attached in full text. (xii) There are no additional contract requirement(s) or terms and conditions applicable to this acquisition. (xiii) The Defense Priorities and Allocations System (DPAS) are not applicable to this requirement. EVALUATION (xiv) The Government may perform a comparative evaluation of responses in accordance with FAR 13.106-2(b) to select the contractor that is best suited and provides the best value, considering the evaluation factors in this solicitation. The evaluation will compare: Technical capability of the item offered to meet the Government requirement in accordance with the salient characteristics specified in the Purchase Description, Price, and Past Performance as defined under FAR 13.106-2(b)(3). If only one quotation is received it will be evaluated on the preceding. The government reserves the right to select a response that provides benefit to the government that exceeds the minimum; the government is not required to select a response that exceeds the minimum; responses may exceed the requirements; each response must meet the solicitation requirement statement at a minimum; and the government is not requesting or accepting alternate proposal(s) SUBMISSION INSTRUCTIONS (xv) Responses to this solicitation must include sufficient information to establish the interested parties’ bona-fide capabilities of providing the product. The price quote shall include: unit price, list price, shipping and handling costs, delivery days after contract award, delivery terms, prompt payment discount terms, F.O.B. Point (Destination or Origin), product or catalog number(s), product description, and any other information or factors that may be considered in the award decision. Such factors may include: past performance, special features required for effective program performance, trade-in considerations, probable life of the item selected as compared with that of a comparable item, warranty considerations, maintenance availability, and environmental and energy efficiency considerations. Respondents proposing on an equal product of the brand-name product specified in this announcement must provide, as part of their response: (a) product, catalog, model, and/or part number(s); (b) product description; (c) all relevant information and documentation that the item(s) offered meets the salient physical, functional, or performance characteristics as specified in the purchase description; quantity; estimated price or cost; shipping, handling, and/or installation charges; and delivery date after receipt of order Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size must be included in the response. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov. All questions must be received by 11:00 a.m., Eastern Time, on April 8, 2021 and reference Solicitation Number 75N95021Q00132. Responses must be submitted by email to Renato Gomes, Contract Specialist, renato.gomes@nih.gov, tel. (301) 451-2596. All quotations must be received by 11:00 a.m., Eastern Time, on April 12, 2021 and reference Solicitation Number 75N95021Q00132. Responses must be submitted by email to Renato Gomes, Contract Specialist, renato.gomes@nih.gov, tel. (301) 451-2596. Fax responses will not be accepted. (xvi) The name and telephone number of the individual to contact for information regarding the solicitation: Renato Gomes Contract Specialist Phone: (301) 451-2596 Email: renato.gomes@nih.gov ATTACHMENTS (xvii) Attachments: FAR 52.204-24, Representation Regarding Certain Telecommunications and Video Surveillance Services or Equipment (Oct 2020) FAR 52.204-26 Covered Telecommunications Equipment or Services-Representation (Oct 2020) FAR 52.212-4 Addendum – Supplier License Agreements FAR 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders–Commercial Items (Jan 2021) FAR 52.225-2, Buy American Certificate (Feb 2021) NIH Invoice and Payment Provisions (Feb 2021) 75N95021Q00132 Department of Health and Human Services National Institutes of Health National Institute on Drug Abuse
4/5/21, 3:10 PM Normal Phase Flash Chromatography with automated Mass Spectrometry
Description: This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; and (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for research and information purposes only. Background: National Center for Advancing Translational Sciences (NCATS) chemists confirm the mass of compounds eluting in fractions collected during flash silica gel purification by manually taking aliquots from several fractions, entering these aliquots to separately located reverse phase Liquid Comatography Mass Spectrometry (LCMS) systems, and then waiting for LCMS results to determine what fractions contain compounds of their interest. NCATS has a requirement for a Normal Phase Flash Comatography with automated Mass Spectrometry such as the Biotage Isolera Dalton 2000 (Brand-name) which will be a dedicated normal flash purification system that will not only collect fractions based on UV but also acquire the mass spectrum of compounds while they are being eluted into fractions. This will significantly cut down the manual step of acquiring the LCMS separately of fractions in order to verify the identity of the compounds. Moreover, the fractions collected in multiple test tubes in the Isolera test tube racks shall be compatible with a Biotage V-10 evaporator (with Gilson liquid handler) that already exists in the lab. This will allow the fractions to be consolidated and concentrated into vials using the V-10/Gilson automation: another significant step towards automation. Purpose and Objectives: The National Center for Advancing Translational Sciences (NCATS) intends to acquire a Normal Phase Flash Comatography with automated Mass Spectrometry in order minimize manual steps in the chemist’s workflow of fraction collection and mass verification for compound identification during purification by comatography. Project requirements: For reference purposes, the normal phase flash purifications comatography system with automated mass directed fraction collection that meets the need of this requirement is the Brand-Name Biotage Isolera Dalton 2000 described below: Part Number (PN) - QTD - Description: ISO-1SV - 1 - Isolera™ One, One Channel, Single Collection Bed, 200-400 nm Detector DALT-2000-APCI-115V - 1 - Biotage Dalton 2000 Mass Detector APCI 115 VAC incl roughing pump DALT-2000-NLINK - 1 - Biotage Dalton 2000 Nanolink DALT-2000-SW - 1 - Spektra License for Dalton 2000 UP-ASAP-SNL - 1 - Dalton 2000 ASAP kit, probe, capillary stand, APCI source port CAP-ASAP - 1 - Dalton 2000 Glass capillaries for ASAP IS-ESI-S01 - 1 - Electrospray Ionization (ESI) ion source 415895SP - 1 - Replacement ESI capillary kit for ALL CMS models (includes capillary, sleeve, and fitting) 415896SP - 1 - Replacement APCI capillary kit (includes capillary, sleeve, and fitting) for S and L CMS models 413320 - 1 - Solvent bottle caps with silicone and nitril septa, 38-430 414506 - 1 - Stylus Pen Kit for capacitive screens 415867 - 1 - ESI Calibration/tune standard mix SER-ISD2K-FYMP - 1 - First Year Maintenance Package - Isolera 1 plus Dalton The salient characteristics of the desired system are listed below: A high-pressure liquid comatography system that can handle purification of organic compounds from reaction mixtures with masses ranging from a few mg to 100 g using silica gel columns of sizes 1g-500g. Automated fraction collection in racks that are compatible with Biotage V-10 evaporator for fraction consolidation. The fraction collections should have the ability to monitor specific UV wavelength and should have an ESI/APCI mass detector to enable collection fractions with a specific mass. Initial installation and familiarization of users on basic operation and maintenance of the system including one Preventive Maintenance visit within 12 months from award. Anticipated period of performance: To be delivered within sixty (60) days after receipt of the order (ARO). Capability statement /information sought. Respondents must provide clear and convincing documentation of their capability of providing the products (brand-name or equal) specified in this sources sought notice. Moreover, interested vendors must provide a capability statement for: the difficulty and/or feasibility of the potential requirement or proposed acquisition, possible solutions and approaches that may currently exist in the marketplace, and information regarding innovative ideas or concepts; and information regarding respondents’: (a) staff expertise, including their availability, experience, and formal and other training; (b) current in-house capability and capacity to perform the work; (c) prior completed projects of similar nature; (d) corporate experience and management capability; and (e) examples of prior completed Government contracts, references, and other related information. The respondent must also provide their DUNS number, organization name, address, point of contact, GSA Schedule Contract, and size and type of business (e.g., 8(a), HubZone, etc., pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements. Submission Instructions: One (1) copy of the response is required and must be in Microsoft Word or Adobe PDF format using 11-point or 12-point font, 8-1/2” x 11” paper size, with 1” top, bottom, left and right margins, and with single or double spacing. The information submitted must be in and outline format that addresses each of the elements of the project requirement and in the capability statement /information sought paragraphs stated herein. A cover page and an executive summary may be included but is not required. The response is limited to ten (10) pages. The 10-page limit does not include the cover page, executive summary, or references, if requested. The response must include the respondents’ technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses. All responses to this notice must be submitted electronically to the Contract Specialist. Facsimile responses are NOT accepted. The response must be submitted to Renato Gomes, Contract Specialist, at e-mail address renato.gomes@nih.gov “Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization’s qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).” HHS-NIH-NIDA-SSSA-21-001875 Department of Health and Human Services National Institutes of Health National Institute on Drug Abuse
3/2/21, 2:06 PM