Purchase Order 75N95019P00697

This federal contract award, valued at $21,400.00, was issued by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) to Enamine US Inc., a for-profit organization. The contract is for ADME (absorption, distribution, metabolism, and excretion) evaluation assays of compounds generated by Enamine. This is a firm fixed-price purchase order with an ultimate completion date of August 27, 2025. Enamine has previously provided various chemical products and research services to the...

The Department of Health and Human Services National Institutes of Health National Center for Advancing Translational Sciences awarded a $29,820 firm fixed price purchase order to Medchemexpress LLC to deliver forty-four bioactive compounds for replenishment and expansion of the Mechanism Interrogation PlatE 6.0 screening library. The compounds will support the Center's high-capacity robotic platform used to screen drug combinations and further its chemogenomic screening capabilities. Delivery...

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $99,000.00 firm-fixed price purchase order to Cyclope Bio SL, a for-profit manufacturer, to acquire Enantiomers of Cyclopentane Diamine and Tetrahydrofuran Diamine. These chemicals are essential starting materials for the NIDDK's Synthetic Bioactive Molecules Section's research on developing new diagnostic kits to detect nucleic acids associated with diseases. The purchase order has a completion date of...

The National Center for Advancing Translational Sciences (NCATS) awarded a purchase order to Karebay Biochem Inc. for $38,600 on May 11, 2026, to provide calibration services for analytical instruments. Work is performed in Rockville, Maryland. The order covers synthesis of two specialized JAK2 inhibitor compounds at 95% purity, confirmed by NMR and LCMS analysis, for brain cancer cell assays: 10 grams of...

The National Institutes of Health National Institute on Drug Abuse awarded a $288,375 firm fixed price purchase order to Curia Global Inc., doing business as Amri, to provide non-GMP synthesis of up to 100 ligands that bind the KIAA0203 protein. Under the terms of the contract, Amri will synthesize the ligands in 2-10 milligram quantities over a one-year period of performance. Amri must dedicate two full-time scientists and one part-time scientist at 25% effort to update progress. There is no...

The National Cancer Institute awarded a $42,941.42 delivery order to Alchem Laboratories Corporation for the non-Good Manufacturing Practice (non-GMP) synthesis of 100 grams of (R)-N-(6-chloro-4-((1-phenylethyl)amino)pyrido[3,4-d]pyrimidin-5-yl)methanesulfonamide (MTX-531), a small molecule compound. The contract was awarded on July 22, 2022, with an ultimate completion date of October 21, 2022, under a cost-plus-fixed-fee pricing structure. This award was designated as a Total Small Business...

The National Institutes of Health's National Center for Advancing Translational Sciences awarded a $99,000 firm fixed price purchase order to Targetmol Chemicals Inc. to synthesize analogs of repsox and intermediates from two ongoing medicinal chemistry projects. Over a six-month period after receipt of order, Targetmol will synthesize the requested compounds and deliver milligram to gram quantities to NCATS along with electronic progress reports, analytical data including LCMS and 1H NMR, and...

This is a $36,000.00 firm fixed-price contract awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), which is part of the National Institutes of Health (NIH), a civilian agency. The contract was awarded to Entrechem SL, a for-profit manufacturer located in Spain, to provide 100g each of two specialized chemical compounds, (1S,2S)-trans-N-Boc-Tetrahydro-3,4-furandiamine and (1R,2R)-trans-N-Boc-Tetrahydro-3,4-furandiamine. These compounds are needed as starting...

Medchemexpress LLC has been awarded a $18,365 firm fixed price purchase order by the Department of Health and Human Services' National Institutes of Health National Center for Advancing Translational Sciences to support the development of cap-dependent endonuclease inhibitors for bunyaviruses. Per the award description, Medchemexpress will provide chemical compounds and research materials to support the agency's biomedical research program aimed at developing inhibitors for this class of...

Specs Chemical Services, Inc. was awarded a $900,000 firm fixed price purchase order by the National Institutes of Health's National Center for Advancing Translational Sciences to deliver a curated collection of over 6,000 screening compounds based on the Broad Institute Repurposing Set. The compounds will support the Center's drug discovery efforts by enabling screening and identification of potential drug candidates. As requested in the solicitation, Specs Chemical Services will provide the...