Purchase Order 75N95019P00369
- Not listed
- This is a firm-fixed-price purchase order contract awarded by the National Center for Advancing Translational Sciences (NCATS), a component of the U.S. Department of Health and Human Services (HHS), to Cyprotex US LLC, a foreign-owned, for-profit contract research organization. The $80,000 contract is for the provision of testing services for 30 compounds, including conducting cytochrome P450 (CYP) inhibition testing, Caco-2 permeability assays, and other absorption, distribution, metabolism,...
- This is a federal contract awarded by the National Center for Advancing Translational Sciences (NCATS), a civilian agency within the Department of Health and Human Services (HHS), to Cyprotex US LLC, a leading contract research organization specializing in predictive toxicology and ADME (absorption, distribution, metabolism, and excretion) research. The $18,024.00 firm fixed-price purchase order contract is for the testing of two compounds against key ADME and DMPK (drug metabolism and...
- This firm fixed price purchase order awards $56,313 to Cyprotex US LLC to provide in vitro absorption, distribution, metabolism, excretion, and toxicity (ADMET) characterization services in support of the Department of Health and Human Services (HHS), National Institutes of Health (NIH), National Cancer Institute's (NCI) Developmental Therapeutics Program (DTP). The contractor will evaluate two small molecule drug candidates total across 11 specified in vitro ADMET assays, including metabolic...
- This is a firm fixed price purchase order awarded by the Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS) to Cyprotex US LLC, a foreign-owned for-profit organization, for $153,215.00 to conduct testing of compounds in absorption, distribution, metabolism, and excretion (ADME) assays over a 1-year period from March 5, 2021 to March 4, 2022. The contract was awarded sole-source without full and open...
- This firm-fixed-price federal contract was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), a civilian agency within the Department of Health and Human Services (HHS), to Cyprotex US LLC, a foreign-owned, for-profit contract research organization. The $12,295.00 contract is for the provision of specialized testing services to support chemical risk assessment, drug development, and environmental research programs. Cyprotex has a significant Indefinite...
- This firm fixed-price purchase order was awarded by the National Cancer Institute (NCI), part of the National Institutes of Health (NIH) within the Department of Health and Human Services (HHS), to Cyprotex US LLC, a foreign-owned for-profit contract research organization. The $157,158 contract is for the characterization of absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties of small-molecule drug candidates using standardized in vitro methods. This work supports...
- This is a firm-fixed-price purchase order awarded by the National Institute on Drug Abuse (NIDA), a civilian agency under the Department of Health and Human Services, to Cyprotex US LLC, a foreign-owned for-profit contract research organization. The $109,392.00 contract is for compound testing services, including plasma protein binding studies, PXR and AhR activation studies, and CYP inhibition assays on various small molecule compounds. This work supports NIDA's mission to seek fundamental...
- This federal contract award provides NCATS (National Center for Advancing Translational Sciences) with testing services for 100 small molecule compounds, including CYP (cytochrome P450) inhibition testing. The $152,000.06 fixed-price purchase order was awarded to Cyprotex US LLC, a foreign-owned, for-profit contract research organization. The contract work is not set aside for small businesses. Cyprotex specializes in predictive toxicology, ADME (absorption, distribution, metabolism, and...
- This is a $50,000.00 firm-fixed-price purchase order awarded by the U.S. Environmental Protection Agency's (EPA) Office of Research and Development to Cyprotex US LLC, a foreign-owned for-profit contract research organization. The contract is for testing of chemical compounds in a human neurite outgrowth assay as part of absorption, distribution, metabolism, and excretion (ADME) and toxicology (ADME-TOX) services. Cyprotex has significant expertise in predictive toxicology, ADME research, and in...
- This $16,260.00 firm-fixed-price purchase order was awarded by the National Center for Advancing Translational Sciences (NCATS), a civilian agency, to Cyprotex US LLC, a foreign-owned for-profit contract research organization. The contract is for COVID-19/coronavirus-related services, including method development for liquid chromatography-mass spectrometry (LC-MS/MS) analysis of 1 compound, and uptake transporter screening/identification for 2 concentrations and 2 time points using a...
Cyprotex US LLC was awarded a $28,100 firm fixed price purchase order by the Department of Health and Human Services' National Institutes of Health's National Institute on Drug Abuse to provide absorption, distribution, metabolism, and excretion testing services of drug compounds. The solicitation requested absorption, distribution, metabolism, and excretion testing including solubility, parallel artificial membrane permeability assay, microsomal stability, liquid chromatography-mass spectrometry method development, hepatocyte stability in mouse and rat models, and Caco-2 permeability bi-directional testing. The contract calls for Cyprotex to deliver the testing services to the National Center for Advancing Translational Sciences within two to three months of receipt of materials. No set-aside provision was applied to this award.
Name | Description | Solicitation Number | FederalAgency | Type | PostedDate |
|---|---|---|---|---|---|
ADME Testing of Drug Compounds (noncompetitive) | 75N95019Q00176 | Department of Health and Human Services National Institutes of Health | Solicitation 1/1 | 6/3/19, 12:28 PM |
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| P00002 | Funding Only Action | ($8k) | 2/21/24 | |
| P00001 | Other Administrative Action | $0 | 6/1/22 | |
| Not listed | Not listed | $36.5k | 6/17/19 |