Delivery Order VA24017D0077-VA24017J0280

This firm fixed price purchase order awards $56,313 to Cyprotex US LLC to provide in vitro absorption, distribution, metabolism, excretion, and toxicity (ADMET) characterization services in support of the Department of Health and Human Services (HHS), National Institutes of Health (NIH), National Cancer Institute's (NCI) Developmental Therapeutics Program (DTP). The contractor will evaluate two small molecule drug candidates total across 11 specified in vitro ADMET assays, including metabolic...

The National Institutes of Health's National Center for Advancing Translational Sciences awarded a $3.86 million firm fixed price purchase order to Molecular Devices LLC for the acquisition of five Molecular Devices ImageXpress Confocal High-Content Imaging Systems, one FLIPR Penta high-throughput cellular screening system, along with associated software, services, consumables, installation, training, customization, maintenance, and technical support. The products and services are to support the...

The National Institute of Environmental Health Sciences awarded a $5,300 firm-fixed price purchase order to Proteinlinks Inc., a woman-owned minority business, for a pilot and large-scale two-hybrid library screening, screening validation, and sequencing project. The work is described as "TAS:: 75 0884:: TAS POTS # 11-011844 INVOICE # 2H0217 PILOT AND LARGE-SCALE TETR BASED TWO HYBRID LIBRARY SCREENING, SCREENING VALIDATION AND SEQUENCING". The contract has a completion date of...

This firm-fixed-price purchase order was awarded by the National Center for Advancing Translational Sciences (NCATS), part of the U.S. Department of Health and Human Services (HHS), to Pharmaron (Exton) Lab Services LLC, doing business as Absorption Systems. The $146,630 contract is for the characterization of the sponsor's test articles via metabolic stability, CYP phenotyping, and in vitro metabolism studies. The contract has no set-aside designation and the work is to be completed by March...

Specs Chemical Services, Inc. was awarded a $900,000 firm fixed price purchase order by the National Institutes of Health's National Center for Advancing Translational Sciences to deliver a curated collection of over 6,000 screening compounds based on the Broad Institute Repurposing Set. The compounds will support the Center's drug discovery efforts by enabling screening and identification of potential drug candidates. As requested in the solicitation, Specs Chemical Services will provide the...

This purchase order awarded by the National Institutes of Health's National Center for Advancing Translational Sciences to BMG Labtech, Inc. is for the delivery of two high-throughput screening multimodal microplate readers. The solicitation requested quotations for readers able to perform fluorescence, luminescence, absorbance, and time-resolved fluorescence assays in an automated fashion when integrated with existing NIH robotic platforms. Valued at $324,474.75, the firm fixed price contract...

This firm fixed-price purchase order for $30,778.40 was awarded by the National Center for Advancing Translational Sciences (NCATS), part of the National Institutes of Health (NIH), to Eurofins Discoverx Products, LLC. The contract is to provide one PathHunter detection kit (PN 93-0001XL) to support NCATS' high-throughput screening efforts for GPR151, a target related to pain and addiction under the NIH HEAL (Helping to End Addiction Long-term) Initiative. Eurofins Discoverx Products was...

This $29,376 firm-fixed-price purchase order was awarded by the National Center for Advancing Translational Sciences (NCATS), a component of the National Institutes of Health (NIH), to Reaction Biology Corporation, a self-certified small disadvantaged business. The award is to obtain kinase hotspot assay compound testing services from Reaction Biology. This contract is not associated with a larger vehicle. The purpose is to test 120 novel small molecule compounds for inhibitory activity...

The National Institutes of Health's National Center for Advancing Translational Sciences awarded a $356,221 firm fixed price purchase order to Synthego Corporation, located in Redwood City, California. Synthego will deliver one Whole Human Genome Arrayed CRISPR Screening Library to the National Institutes of Health campus in Rockville, Maryland by September 3, 2021. The library, as requested in the solicitation, will contain up to three chemically modified synthetic sgRNAs per well targeting...

This is a firm fixed price purchase order awarded by the Department of Health and Human Services (HHS) National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS) to Cyprotex US LLC, a foreign-owned for-profit organization, for $153,215.00 to conduct testing of compounds in absorption, distribution, metabolism, and excretion (ADME) assays over a 1-year period from March 5, 2021 to March 4, 2022. The contract was awarded sole-source without full and open...