Delivery Order EPD15016-0001

This firm fixed price purchase order awards $56,313 to Cyprotex US LLC to provide in vitro absorption, distribution, metabolism, excretion, and toxicity (ADMET) characterization services in support of the Department of Health and Human Services (HHS), National Institutes of Health (NIH), National Cancer Institute's (NCI) Developmental Therapeutics Program (DTP). The contractor will evaluate two small molecule drug candidates total across 11 specified in vitro ADMET assays, including metabolic...

The U.S. Environmental Protection Agency (EPA) Office of Research and Development awarded a $451,818 firm fixed-price delivery order to Cyprotex US LLC on December 30, 2024, under an existing Indefinite Delivery Indefinite Quantity (IDIQ) contract for high throughput toxicokinetics (HTTK) testing services. This Task Order #7 represents continued support for the EPA's HTTK program, which enables the agency to rapidly and cost-effectively generate toxicokinetic data on industrial chemicals and...

This delivery order, issued May 20, 2024, represents Task Order 1 under Evotec US Inc.'s single-award Indefinite Delivery/Indefinite Quantity (IDIQ) contract with the U.S. Environmental Protection Agency's Office of Research and Development. Valued at approximately $200K with a firm fixed price and a completion date of May 19, 2025, the task order covers chemical procurement, analysis, sample preparation, and management services to be performed in Durham, North Carolina. The award was made...

This is a $50,000.00 firm-fixed-price purchase order awarded by the U.S. Environmental Protection Agency's (EPA) Office of Research and Development to Cyprotex US LLC, a foreign-owned for-profit contract research organization. The contract is for testing of chemical compounds in a human neurite outgrowth assay as part of absorption, distribution, metabolism, and excretion (ADME) and toxicology (ADME-TOX) services. Cyprotex has significant expertise in predictive toxicology, ADME research, and in...

This is a federal contract awarded by the National Center for Advancing Translational Sciences (NCATS), a civilian agency within the Department of Health and Human Services (HHS), to Cyprotex US LLC, a leading contract research organization specializing in predictive toxicology and ADME (absorption, distribution, metabolism, and excretion) research. The $18,024.00 firm fixed-price purchase order contract is for the testing of two compounds against key ADME and DMPK (drug metabolism and...

This is a firm fixed price delivery order awarded by the Environmental Protection Agency's Office of Research and Development to Evotec US Inc., a foreign-owned, for-profit organization. The order, valued at $399,804.80, is for toxicology data generation services under the ToxCast chemical prioritization program, including chemical procurement, analysis, sample preparation, and management. Evotec has provided similar services to the EPA under several prior delivery orders against the larger...

This is a firm fixed-price purchase order awarded by the National Institutes of Health (NIH) to Pharmaron, Inc. for $75,600 to conduct ion channel block, IC50 determination testing on 60 compounds over a period of 12 months. The work supports drug discovery and development efforts for the National Center for Advancing Translational Sciences (NCATS) and involves evaluating compounds for potential cardiotoxicity. The contract does not have a set-aside designation. Pharmaron is a global contract...

The National Center for Advancing Translational Sciences (NCATS) awarded a $11,340 firm fixed-price purchase order to BPS Bioscience Inc. for a biochemical IC50 screening study. The contract calls for the vendor to conduct inhibitory concentration testing on twelve compounds plus one control against three protein kinase targets: PKM2, PKL, and PKR. This procurement supports NCATS's mission to accelerate the translation of laboratory discoveries into clinical applications by providing critical...

The National Center for Advancing Translational Sciences issued a delivery order to Organix Chemistry Solutions LLC on September 28, 2020, with a ceiling value of $3.674 million, under the master IDIQ for CRO Support for NCATS Medicinal Chemistry for Lead Optimization. The order calls for synthetic chemistry support services to the Therapeutics Development Branch Medicinal Chemistry Team on a cost-no-fee basis. Place of performance is Woburn, MA. The period of performance ran from September...

This is a firm-fixed-price task order awarded by the U.S. Environmental Protection Agency's (EPA) Office of Research and Development to Evotec US Inc., a foreign-owned, for-profit organization. The $48,153.95 task order was issued under an Indefinite Delivery/Indefinite Quantity (IDIQ) contract for chemical procurement, analysis, sample preparation, and management services in support of the EPA's ToxCast chemical screening program. The IDIQ contract, valued at $16,123,957.10, was originally...