The National Science Foundation (NSF) is offering the Computational and Data-Enabled Science and Engineering (CDS&E) grant opportunity to support projects that harness computation and data to advance scientific and engineering knowledge. The goal is to identify and capitalize on opportunities for major breakthroughs through new computational and data-analysis approaches. Proposals must have a significant component of computational or data science that goes beyond what would normally be included in existing programs. Applicants should submit proposals to the relevant NSF division based on the specified submission windows, which range from September to November annually. Proposals should enable and/or utilize advances in computational and data science research and infrastructure to address intractable science and engineering problems. The CDS&E grant program does not have a specified award amount, but typical NSF Engineering and Mathematical and Physical Sciences grants range from $250,000 to $650,000 for project periods of 3-5 years. The awards support a wide range of research areas, including materials science, bioengineering, quantum technologies, and computational science, at academic institutions and research organizations across the United States.